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他莫昔芬以20mg/d的剂量给药5年,对乳腺癌的治疗和预防有效,但毒性限制了其广泛使用。
Tamoxifen administered for 5 years at 20 mg/d is effective in breast cancer treatment and prevention, but toxicity has limited its broad use.
他莫昔芬的妇女应密切监测症状的子宫内膜增生或癌症,应该有一个妇科检查,至少每年一次。
Women taking tamoxifen should be monitored closely for symptoms of endometrial hyperplasia or cancer and should have a gynecologic examination at least once every year.
他莫昔芬在乳腺癌治疗中的作用的初步结果显得那么乐观,进一步研究提出严重关切,它的广泛使用。
While the initial findings of Tamoxifen's role in breast cancer treatment seemed so promising, further research presented grave concerns for its widespread use.
一项针对他莫昔芬一级预防试验的meta分析表明,乳腺癌发病率降低了38%,没有统计学显著的异质性。
A meta-analysis of these primary prevention tamoxifen trials showed a 38% reduction in the incidence of breast cancer without statistically significant heterogeneity.
激素受体阴性的肿瘤不会回应他莫昔芬,和肿瘤没有过表达HER2的不会回应反erbB2的药物曲妥单抗(赫赛汀)。
Hormone receptor-negative tumors will not respond to tamoxifen, and tumors that do not overexpress HER2 will not respond to the anti-erbB2 drug trastuzumab(Herceptin.
另外一项研究表明,仔细选择的70岁以上的患者在乳房肿瘤切除术后用他莫昔芬治疗时,放疗没有额外的生存获益。
An additional study demonstrated that carefully selected patients aged 70 and older had no additional survival benefit with radiation therapy when treated with tamoxifen after lumpectomy.
这种系统需要两把“钥匙”---药物他莫昔芬(Tamoxifen)和蓝光---来激活CAR-T细胞,使得它们能够结合它们的靶标。
The system requires two“keys”- the drug Tamoxifen and blue light- to activate CAR T cells to bind to their targets.
三个月之后,超过250位女性完成了第二个调查问卷,这些问卷记录了他们是否决定开始使用他莫昔芬
After three months, more than 250 women completed a second questionnaire that recorded their decision on whether to start using the drug.
他莫昔芬帮助许多女性罹患乳腺癌并延长生命。
Tamoxifen has helped many women beat breast cancer and extend their lives.
总增加妇女谁使用他莫昔芬在所有的风险是50%。
The total increased risk for all women who used tamoxifen at all was 50.
他莫昔芬:用于预防某些乳腺癌。
Abemaciclib: Used for certain types of breast cancer.
一般来说,他莫昔芬在三个不同的背景下实施有三个主要原因.
Generally speaking, Tamoxifen is implemented for three main reasons, in three different contexts.
为了避免这种情况,他莫昔芬应与AI(芳香酶抑制剂)一起使用。
In order to avoid this, Tamoxifen should be used alongside an AI(aromatase inhibitor.
他莫昔芬是作为化学预防妇女乳腺癌高风险的代理批准的第一个药物。
Tamoxifen is the first drug approved as chemoprevention agent for women at high-risk for breast cancer.
他莫昔芬是乳腺癌的药物,已经使用了几十年来治疗疾病和阻止它回来。
Tamoxifen is a breast cancer drug that has been available for decades to treat the disease and stop it coming back.
L他莫昔芬(Nolvadex,Tamofen)用于绝经前和绝经后妇女。
Tamoxifen(Nolvadex, Tamofen) is given to premenopausal and post-menopausal women.
使用的动物模型与40多年前用于发现他莫昔芬可以预防乳腺癌的模型相同。
The animal model used is the same that was used over 40 years ago to discover that tamoxifen prevents breast cancer.
抑郁症已报道%的女性30他莫昔芬作为一个潜在的副作用。
Depression has reported as a potential side-effect of tamoxifen in 30% of women.
他莫昔芬使用应仅限于5年的时间,因为受益超出这个时间还没有记载。
Tamoxifen use should be limited to 5 years' duration because a benefit beyond this time has not been documented.
他莫昔芬20mg/天剂量通常被视为先进,辅助和预防设置的最佳剂量。
A 20 mg/day dose of tamoxifen is generally viewed as the optimal dose in the advanced, adjuvant, and prevention settings.