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Imikvimod krema ispitivana je biološkim testiranjem fotokancerogenosti kod albino bezdlakih miševa koji su bili izloženi simuliranom sunčevom ultravioletnom zračenju.
Imiquimod cream was evaluated in a photocarcinogenicity bioassay in albino hairless mice exposed to simulated solar ultraviolet radiation UVR.Imikvimod krema primjenjivana je tri puta tjedno
Animals were administered imiquimod cream three times per weekKod životinjskih modela imikvimod je učinkovit protiv virusnih infekcija
In animal models imiquimod is effective against viral infectionsNa životinjama je primijenjena imikvimod krema tri puta tjedno
Animals were administered imiquimod cream three times per weekIzračunati prividni poluvijek nakon topikalnog doziranja imikvimod 3, 75% kreme u farmakokinetičkom ispitivanju bio je približno 29 sati.
The apparent half-life following topical dosing of 3.75% imiquimod cream in the pharmacokinetic study was calculated as approximately 29 hours.Zbog njezinih imunostimulativnih svojstava imikvimod kremu treba oprezno primjenjivati u bolesnika koji uzimaju imunosupresivne lijekove vidjeti dio 4.4.
Due to its immunostimulating properties, imiquimod cream should be used with caution in patients who are receiving immunosuppressive medication see Section 4.4.Imikvimod krema ispitivana je u biotestu fotokancerogenosti na albino bezdlakim miševima izloženima simuliranom sunčevom ultraljubičastom zračenju engl. ultraviolet radiation UVR.
Imiquimod cream was evaluated in a photocarcinogenicity bioassay in albino hairless mice exposed to simulated solar ultraviolet radiation UVR.rijetko se mogu javiti nakon samo nekoliko primjena imikvimod kreme.
erosion can occur after only a few applications of imiquimod cream.Imikvimod kremu je potrebno primijeniti u tankom sloju na čisto područje s bradavicama
Imiquimod cream should be applied in a thin layer and rubbed on the clean wartNa životinjskim modelima imikvimod je učinkovit protiv virusnih infekcija
In animal models imiquimod is effective against viral infectionsKako imikvimod ima nisku sistemsku apsorpciju kroz ljudsku kožu
As imiquimod has low systemic absorption from human skin,Lokalna primjena imikvimod kreme u bilo kojoj dozi nije dovela do povećanja tumora u usporedbi sa skupinom koja je dobivala kremu bez imikvimoda.
Topical administration of imiquimod cream resulted in no tumour enhancement at any dose, in comparison with the vehicle cream group.Imikvimod potiče otpuštanje interferona alfa(IFN-α)
Imiquimod induces the release of interferon alpha(IFN-α)Mehanizam ove pojave nije poznat, ali kako imikvimod ima nisku apsorpciju putem kože i nije mutagen,
The mechanism for this is not known, but as imiquimod has low systemic absorption from human skin,Topikalna primjena imikvimod kreme nije rezultirala povećanjem broja tumora pri bilo kojoj dozi u usporedbi sa skupinom na kojoj je primijenjena krema od same podloge.
Topical administration of imiquimod cream resulted in no tumour enhancement at any dose, in comparison with the vehicle cream group.Topikalna in vivo primjena imikvimod kreme na mišjoj koži rezultirala je povećanim kocentracijama IFN-a
Topical in vivo application of imiquimod cream on mouse skin resulted in increased concentrations of IFNIspitivanja zasićenja vezivanja upućuju na to da membranski receptori za imikvimod postoje na stanicama koje reagiraju na njega,
Saturable binding studies suggest membrane receptors for imiquimod exists on responding cells;Mora se izbjegavati istodobna primjena Zyclare i drugih imikvimod krema na istom području koje se liječi jer sadrže istu djelatnu tvar(imikvimod)
Concomitant use of Zyclara and any other imiquimod creams in the same treatment area should be avoided since they contain the same active ingredient(imiquimod)Prijavljena je lokalna hipopigmentacija i hiperpigmentacija nakon primjene imikvimod kreme.
Reports have been received of localised hypopigmentation and hyperpigmentation following imiquimod cream use.Nakon smirivanja kožne reakcije liječenje imikvimod kremom može se nastaviti.
Treatment with imiquimod cream can be resumed after the skin reaction has moderated.
