CLOFARABIN in English translation

• clofarabine

Examples of using Clofarabin in Danish and their translations into English

De bør anvende sikker prævention under og efter behandling med clofarabin.
Women who are able to get pregnant: you must use effective contraception during and after treatment with clofarabine.

Det vides ikke, om clofarabin eller dets metabolitter udskilles i human modermælk.
It is unknown whether clofarabine or its metabolites are excreted in human breast milk.

Erfaringsgrundlaget er endnu utilstrækkeligt til at påvise sikkerhed og effekt af clofarabin til voksne patienter.
There are currently insufficient data to establish the safety and efficacy of clofarabine in adult patients.

Erfaringsgrundlaget er endnu utilstrækkeligt til at påvise sikkerhed og effekt af clofarabin til ældre patienter.
There are currently insufficient data to establish the safety and efficacy of clofarabine in elderly patients.

Hvis en patient udvikler en klinisk signifikant infektion, kan clofarabin seponeres, indtil infektionen er velkontrolleret.
If a patient develops a clinically significant infection, clofarabine treatment may be withheld until the infection is clinically controlled.

Clofarabin indtager adenins plads i kroppen
In the body, clofarabine takes the place of adenine,

Der foreligger kun begrænsede data om sikkerhed og effekt af clofarabin ved anvendelse ud over 3 behandlingscykler.
There are currently limited data on the safety and efficacy of clofarabine when administered for more than 3 treatment cycles.

Toksikologiske undersøgelser af clofarabin hos mus, rotter
Toxicology studies of clofarabine in mice, rats

Glomerulonefropati rapporteredes hos rotter efter 3- 5 gange større eksponering end det kliniske AUC efter 6 behandlingscykler med clofarabin.
Glomerulonephropathy was reported in rats at exposure levels 3 to 5 fold higher than the clinical AUC after 6 dosing cycles of clofarabine.

Da clofarabin imidlertid ikke metaboliseres af cytochrom P450-(CYP-) enzymsystemet,
However, as clofarabine is not detectably metabolised by the cytochrome P450(CYP)

Clofarabin har høj affinitet til et af de aktiverende phosphorylerende enzymer,
Clofarabine has high affinity for one of the activating phosphorylating enzymes,

Endvidere forhalede clofarabin tumorvækst og medførte i nogle tilfælde tumorregression hos en række humane
In addition, clofarabine delayed tumour growth and, in some cases, caused tumour regression

Det aktive stof i Evoltra, clofarabin, er et cytotoksisk lægemiddel, som tilintetgør celler, der deler sig,
The active substance in Evoltra, clofarabine, is a cytotoxic a medicine that kills cells that are dividing,

Det aktive stof i Evoltra, clofarabin, er en cellegift et lægemiddel, der dræber celler, der deler sig,
The active substance in Evoltra, clofarabine, is a cytotoxic a medicine that kills cells that are dividing,

Der er ingen erfaring med patienter med nyreinsufficiens(serum- kreatinin ≥ 2 x ULN for aldersgruppen), og clofarabin udskilles hovedsageligt via nyrerne.
There is no experience in patients with renal insufficiency(serum creatinine≥ 2 x ULN for age) and clofarabine is predominately excreted via the kidneys.

ASAT forekom inden for 1 uge efter administration af clofarabin og var forbigående de varede typisk< 2 uger.
AST occurred within 1 week of clofarabine administration and were transient typically of< 2 weeks duration.

In vitro- forsøg har vist, at clofarabin hæmmer cellevækst i
In vitro studies have demonstrated that clofarabine inhibits cell growth in

I tilfælde af en til klinisk signifikant infektion bør clofarabin seponeres, indtil infektionen er velkontrolleret, og den kan genoptages, hvis dosis reduceres med 25.
In the event of a second clinically significant infection, clofarabine treatment should be withheld until the infection is clinically controlled and may be reinitiated at a 25% dose reduction.

Når patienten er stabiliseret, og organfunktionen atter er som ved baseline, kan det overvejes at fortsætte behandlingen med clofarabin, dog generelt i en lavere dosis.
Further treatment with clofarabine, generally at a lower dose, can be considered when patients are stabilised and organ function has returned to baseline.

Clofarabin bør omgående seponeres, hvis patienten udviser nogle af de tidlige symptomer
Clofarabine should be discontinued immediately if patients show early signs