Examples of using Compared with placebo in English and their translations into Japanese
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Two randomized, placebo-controlled trials indicated that erlotinib prolongs survival and time to deterioration in symptoms in patients with NSCLC after first-line or second-line chemotherapy compared with placebo[11][12] but does not improve survival compared with standard second-line chemotherapy with docetaxel or pemetrexed.[13].
Compared with placebo, abiraterone was also associated with delay in median time to deterioration in the FACT-P QOL score(59.9 weeks vs. 36.1 weeks, P< .0001) and clinically important improvement in QOL in men with functional status impairment at baseline(48% vs. 32%, P< .0001).
A randomized placebo-controlled trial of 432 patients failed to show improvement in dyspnea or anxiety with the nonbenzodiazepine anxiolytic drug buspirone compared with placebo in cancer patients who had moderate to severe dyspnea, although the dose of 20 mg was relatively low;[44][Level of evidence: I] buspirone cannot be recommended at this time for the treatment of dyspnea in cancer patients.
On a standard depression scale, which rates depression from zero(not depressed) to 52(most severely depressed), the drugs improve things by an average of about two points, compared with placebos in adults.
DeRubeis of the University of Pennsylvania, found that compared with placebos, the drugs caused a much steeper reduction in symptoms of severe depression(cases scoring 25 or higher on a standard scale of severity, putting them in the top quarter of the sample).
Treatment with BAF312 reduced the risk of three-month confirmed disability progression by 21% compared with placebo(p=0.013).
In this same study, daily supplements containing folic acid, vitamin B6, and vitamin B12 were compared with placebo;
Brain scans of patients showed that the process stalled LMTX death of nerve cells on 33-38% compared with placebo.
A study found that after one week of supplementing with stinging nettle, allergic symptoms were reduced compared with placebo(11).
In a 4-year clinical study, orlistat significantly reduced the risk of type 2 diabetes(by about 37% compared with placebo).
There was no statistically significant difference in the number of people who died during treatment with formoterol compared with placebo or salbutamol.
Compared with placebo, trimethobenzamide 200 mg IM every 6 hours for 2 days significantly reduced episodes of nausea and vomiting.[18].
The primary objective of the study was to demonstrate improvement in overall survival with the combination of aflibercept and docetaxel compared with placebo and docetaxel.
In another trial of 371 randomly assigned adult patients with metastatic soft tissue sarcoma that progressed after chemotherapy, pazopanib was compared with placebo.[46].
This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown.
To evaluate the safety and the topical efficacy of Cortexolone 17α-propionate 1% cream in acne vulgaris as compared with placebo and with tretinoin 0·05% cream.
Delivered on the Web, positive psychology exercises relieved depressive symptoms for at least 6 months compared with placebo interventions, the effects of which lasted less than a week.
Compared with placebo, supplementation with vitamin C(500 mg/day) for an average of 9.4 years had no significant effect on total cancer incidence or cancer mortality.
In this same study, daily supplements containing folic acid, vitamin B6, and vitamin B12 were compared with placebo; this intervention was not efficacious in reducing the overall risk of developing cancer.
While a gradual and progressive increase in the number of high-grade tumors would have been expected over the study duration of 7 years, when compared with placebo, this was not the case.