Примери за използване на Sirolimus на Английски и техните преводи на Български
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Sirolimus concentrations were measured in concentration-controlled studies of paediatric renal-transplant patients who were also receiving ciclosporin and corticosteroids.
Whole blood sirolimus Cmax, tmax, and AUC were increased 4.4-fold,
Sirolimus Cmax, tmax,
The safety and efficacy of sirolimus as immunosuppressive therapy have not been established in lung-transplant patients;
Currently in clinical practice, sirolimus whole blood concentrations are being measured by various chromatographic and immunoassay methodologies.
The safety and efficacy of sirolimus as immunosuppressive therapy have not been established in liver
In patients with delayed graft function receiving sirolimus could slow down the recovery of renal function.
Voriconazole increased sirolimus(2 mg single dose)
colleagues plan to start a clinical trial to test sirolimus in up to 24 patients with iMCD.
Therapeutic monitoring of the medicinal product should not be the sole basis for adjusting sirolimus therapy.
The effect of CsA was also reflected by increases in sirolimus Cmax and tmax.
If diltiazem is administered, sirolimus blood levels should be monitored and a dose adjustment may be necessary.
Rare reports of fatal hepatic necrosis have been reported with elevated trough sirolimus levels.
In hepatically impaired patients, it is recommended that sirolimus whole blood trough levels be closely monitored.
Inhibitors of P-gp may decrease the efflux of sirolimus from intestinal cells and increase sirolimus levels.
Inhibitors of CYP3A4 may decrease the metabolism of sirolimus and increase sirolimus blood levels.
decrease the metabolism of sirolimus and increase sirolimus levels.
Therapeutic drug monitoring should not be the sole basis for adjusting sirolimus therapy.
Sirolimus concentrations should be measured upon initiation, during co-administration, and at discontinuation of posaconazole treatment, with sirolimus doses adjusted accordingly.
If you have been taking sirolimus together with cyclosporine for 2 to 4 months after your transplant,