In addition to estrogen, levels of other hormones produced by the ovaries- progesterone(another female hormone) and testosterone(a male androgen hormone produced at lower levels in women)- are also changing during your midlife years, as explained in the table below.
It has an inhibitory effect on the human body's humoral immune response and inhibits the immunoglobulin produced by human peripheral blood mononuclear cells.
Many changes during the years leading up to menopause(perimenopause) are brought on by changing levels of hormones produced by the ovaries, mainly oestrogen.
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