Children younger than 5 years at diagnosis were more likely to have IQs below 80 at 3 years posttherapy than were children older than 5 years at diagnosis, irrespective of treatment allocation, suggesting that younger children are more vulnerable to treatment-related neurologic toxic effects.
A study of opioid rotation in the outpatient palliative care setting revealed that approximately one-third of 385 consecutive patients needed an opioid rotation, mostly for uncontrolled pain(83%) and opioid-induced neurotoxicity(12%).
An article published in Science in 2002 on the neurotoxicity of the drug MDMA("ecstasy") caused some controversy when a mix-up of vials caused the paper to be retracted in 2003(see Retracted article on dopaminergic neurotoxicity of MDMA).
Evaluations included pre- and post-treatment scores of the Research and Development Corporation(RAND) 36-item Short Form Health Survey(SF-36) in comparison with RAND population norms, pre- and post-treatment symptom score intensities, neurotoxicity scores, Mini-Mental Status Examination, presenting symptom frequencies and a structured evaluation of treatment program safety.
Second, recent research has demonstrated MA's neurotoxicological effects in animals and has begun to support the hypothesis that MA is neurotoxic in humans.
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