Moreover, they found that the three-dimensional structure of band 3 is similar to that of ClC-type chloride ion channels, *6 the structure of which has already been clarified.
As the research progressed, he changed the analysis method from electron microscopy to X-ray crystallography in order to examine the steric structure of the proteins in more detail.
With precise and detailed calculation in order to make best use of the three-dimensional structure, a characteristic special to dyed pattern fabric, the fabric shows different expressions depending on the light and angle.
The detailed research results were reported in Nature(June 2000), and the world first 3D structure image of calcium pumps appeared on the cover of the journal.
So I decided to use the three-dimensional structures that analysis had revealed to try to develop compounds that would be useful for treatment by preventing prions from lodging in pockets on protein surfaces and transforming proteins to abnormal structures..
Prof. Namba believes that the 3D structure of not only proteins but also any of the other biomolecular complexes, including lipids and nucleic acids, will be visualized in 5 years.
The research group clarified the three-dimensional structure of the dynein motor for the first time in the world by crystallizing a perfectly functioning dynein motor of cellular slime molds Fig.
Database Description- RPSD| LSDB Archive We have determined the three-dimensional structures of the protein of seven kinds of plants such as rice, and have put together the result and related informations.
To understand vital functions and efficiently design medicines that work only on target molecules, it is very important to clarify the three-dimensional structure of membrane proteins.
In the case of one of the extremely thermophilic model organisms, Thermus thermophilus HB8, the three-dimensional structures of 22% of 2,200 proteins have already been determined.
This database contains the basic information of the protein, that assumed Protein Data Bank a source of information, experimental methods used for the structure determination, literature information, sequence, the image of the three-dimensional structures, and so on.
Thus far, however, the steric structures of low-molecular-weight compounds that selectively block specific G proteins and the binding sites of such compounds have not been clarified, hampering the development of new drugs.
Out-of-the-box crystallization technique For the analysis of the steric structureof proteins, crystals with a size and a uniformity(precision in terms of alignment) that are suitable for the analytical technique used should be prepared.
By three-dimensional structural and biochemical analyses, we also found that the major cause of this instability of the nucleosome containing histone H3T is the 111th valine residue, which is specific to histone H3T.
Determination of the 3D structuresof flagellin molecules requires crystal molecules to be perfectly aligned. Crystallization of flagellin molecules was difficult, since they tend to be polymerized in a long fibrous form.
In our laboratory, we have been measuring the electron transfer reaction, the function of cytochrome C and other electron transfer proteins, and working to elucidate the mechanism of reaction with the use of information on the tertiary structure.
We would like to conduct joint research to elucidate the tertiary structure of a protein interacting with some other proteins or new drugs that are now being developed by drug researchers or manufacturers.
Learn the structure of the accelerator moving mechanism and elementary particles, observe cosmic rays falling from space, see the three-dimensional structure of proteins visually, and measure radiation contained in familiar oneself be able to.
It was clarified that the steric structure of DSB was changed from a twisted to a planar structure emitting strong blue fluorescence owing to the structural change in the PCP pores Figs.3 and 4.
In order to understand the basic principles of life, it is important to clarify the molecular mechanism by which YidC inserts membrane proteins. However, the three-dimensional structure of YidC remained unknown for a long time, and the mechanism of membrane protein insertion remained to be elucidated.
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