Maybe you need more of the other cell types to help regulate the beta cells, so that they function correctly.
Prabhakar指出:“没有这个基因,胰岛素就不能离开β细胞,血糖水平就会慢性地升高。
As Prabhakar puts it,“Without the gene, insulin can't leave the beta cells, and blood glucose levels are chronically high.”.
但研究人员仍然不知道这些β细胞蛋白是如何第一次遇到免疫细胞并触发自身免疫的。
But researchers still didn't know how these beta-cell proteins first encountered the immune cells that trigger autoimmunity.
此外,一些β细胞产生胰高血糖素的细胞,这可以解释为什么糖尿病人胰高血糖素水平异常高的。
In addition, some of the beta cells became glucagon-producing cells, which would explain why people with diabetes have abnormally high glucagon levels.
顾臻博士决定创建一种设备,让β细胞的血糖缓冲特性远离病人免疫系统达到的地方。
Gu decided to create a device that would put the blood-sugar buffering properties of beta cells out of reach of the patient's immune system.
如果β细胞被破坏或失去功能,可能会导致如糖尿病那样的严重疾病。
If the beta cells are destroyed or lose their function, this can lead to serious diseases such as diabetes.
他们说道:“人们都知道糖尿病人缺乏β细胞,因为它们在2型糖尿病患者中耗光了。
They said:"People knew there was a lack of beta cells because they die off in type 2 diabetes.
在高葡萄糖环境中,β细胞中维生素D受体的表达降低。
In a high-glucose environment, the expression of vitamin D receptors in the beta cells was reduced.
数十年来对动物和细胞模型的研究扩大了对导致β细胞功能障碍的分子机制的认识。
Decades of research with animal and cellular models have expanded the knowledge on the molecular mechanisms causing the beta-cells to dysfunction.
然而,这种技术是昂贵的,这是因为β细胞不得不为每名病人单独地制造。
This technique is expensive, however, since the beta cells have to be produced individually for each patient.
目前一些市售药物均为GLP-1激动剂,但现有疗法采用的方式无法阻断炎症导致的β细胞功能受损。
Currently, some commercially available drugs are GLP-1 agonists, but the existing treatments cannot block the damage of β-cell function caused by inflammation.
令人更加惊喜的是,在一个500mL的烧瓶中可以产生2亿个β细胞;
It is more a surprise that, in a 500 mL flask can produce 200 million β cells;
相比之下,这个新过程可以成功地把四分之三的脂肪干细胞转变为β细胞。
In contrast, the new process could successfully transform three out of four fatty tissue stem cellsinto beta cells.
相比之下,这个新过程可以成功地把四分之三的脂肪干细胞转变为β细胞。
This new process can successfully transform three out of four fat stem cellsinto beta cells.
相比之下,这个新过程可以成功地把四分之三的脂肪干细胞转变为β细胞。
In contrast, the new process can successfully transform three out of four adipose stem cellsinto beta cells.
胰岛素是一种激素所产生并存储在β细胞胰腺。
Insulin is a hormone that is produced and stored in the beta cells of the pancreas.
Preceding work of our collaborator, Patrick Collombat's team showed that a genetic knockout of Arx leads to a transformation of alpha cellsinto beta cells.”.
Β细胞在你的血液中释放胰岛素,但当你患有1型糖尿病时,你几乎没有任何一种留在你的身体里的β细胞。
Beta cells release insulin in your blood, but when you suffer from Type 1 diabetes, you hardly have any of them left in your body.
However, islets(with beta cells) donated from deceased persons with type 2 diabetes have more VDAC1 and less VDAC2, compared to islets from healthy donors.
型糖尿病由β细胞的破坏导致。
Type 1 diabetes is caused by the destruction of beta cells.
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