X连锁眼白化病可由携带一个突变 X基因的母亲传给儿子(X连锁隐性遗传)。 X-linked ocular albinism can be passed on by a mother who carries one mutated X gene to her son(X-linked recessive inheritance). 现在,研究者认为他们知道为什么:一个突变 ,使一些流感病毒打败了疫苗。 Now, researchers think they know why: a mutation that enabled some flu viruses to beat the vaccine. 亿是一个巨大的数字,无极4荣耀代理它可以确定一个突变 可能发生在哪里--这几乎是不可能的,手动。 Three billion is a massive number to identify where a mutation can occur- it's virtually impossible, manually. This genetic change is one that is acquired during a person's lifetime and is not inherited. 在大部分患者中(10-40%),只鉴定出一个突变 的等位基因。 In a large fraction(10-40%) of patients, only one mutant allele is identified.
里佐说,父母对他们进行了测试的所有七个同父异母的兄弟姐妹中,至少有一个突变 。 Rizzo said all seven of the half-siblings whose parents had them tested have at least one of these mutations . 在第三个家庭具有POI的女性具有该基因家族的另一个突变 -MCM8。 The women with POI in the third family had a mutation in another gene in the family, MCM8. 每次您按变异,Absynth增加了一个突变 历史的新条目。 Each time you press“Mutate”, Absynth adds a new entry to the Mutation History. 最终,他们在Massimo的基因组中发现了一个突变 ,有可能解释这些症状。 He found a mutation in Massimo's genome that he thought might explain the symptoms. 但是,如果G以某种方式与T错配,那么这将是一个突变 。 However, if G were to somehow mispair with T, for example, that would be a mutation . 它是具有最常见基因突变的CF患者中第一种这样做的药物-90%的患者至少具有一个突变 拷贝。 It is the first drug to do so in CF patients with the most common gene mutation- 90% have at least one copy of the mutation . 这三个突变(YAP1,M89T和M130T)可溯祖到另一个突变 (M168T),它约在35,000-89,000年前起源于非洲。 The three mutations(M89T, M130T, YAP+) coalesce to another mutation (M168T), which was originally derived from Africa about 31000 to 79000 years ago. 妇女谁运营商,有一个突变 和一个正常的基因拷贝(杂),都会有一些红细胞这是G6PD缺乏和一些不。 Women who are carriers, having one mutated and one normal gene copy(heterozygous), will have some RBCs that are G6PD-deficient and some that are not. 如果有一个突变 (变体)中的一个或两个基因拷贝,则较少AAT和/或功能障碍的AAT被产生。 If there is a mutation (variant) in one or both of the gene copies, then less AAT and/or dysfunctional AAT is produced. 这三个突变(YAP1,M89T和M130T)可溯祖到另一个突变 (M168T),它约在35,000-89,000年前起源于非洲。 These three mutations(YAP, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. 前言:基因治疗的概念其实很简单:如果一个突变 基因引起了问题,就用一个新的正确的拷贝来取代或是补充它。 The concept is simple: if a mutated gene is causing a problem, replace or supplement it with a new, accurate copy. 这三个突变(YAP,M89,M130)合并到另一个突变 (M168),M168约起源于35,000至89,000年前的非洲。 These three mutations(YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. 这是另一个挑战异质性肿瘤,这些是由多个基因突变驱动的-如果你针对一个突变 ,在其他人会茁壮成长“。 Another challenge is that these are heterogenous tumors driven by multiple mutations- if you target one mutation , others will thrive.”. We are already seeing the next mutation . I watched The Next Mutation .
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