To understand how disruption of gigaxonin's function leads to neurodegeneration, we ablated the gene expression in mice using traditional gene targeting approach.
在发现放线菌中的这些基因及其工作方式后,研究人员研究了这些基因在其他微生物中的分布情况。
After discovering these genes in actinomycetes and how they work, the investigators studied how widespread these genes are in other microorganisms.
他们利用机器学习开发了PUR测试,从537名男性收集的样本中查看尿液中的基因表达。
They developed the Prostate Urine Risk(PUR) test using machine learning to look at gene expression in urine from samples collected from 537 men.
By using CRISPR, scientists are able to tweak specific genes in viruses or the body's own immune cells, and so make them behave differently.
在这项最新的研究中,研究人员首次利用基因编辑,成功交换了一个动物遗传密码中的等位基因。
This latest study marks the first time researchers have successfully swapped alleles in an animal's genetic code using gene editing.
年,美国科学家宣布,他们使用CRISPR编辑人类胚胎中的基因,来纠正导致心脏缺陷的突变。
In 2017, U.S. scientists announced that they had used CRISPR to edit genes in human embryos to correct a mutation that causes a heart defect.
为了测试其对帕金森氏病的影响,Yue和他的团队敲除了小鼠黑质中的STMN2基因。
To test its influence on Parkinson's disease, Yue and his team knocked down the STMN2 gene in the substantia nigra of the mice.
在这项最新的研究中,研究人员首次利用基因编辑,成功交换了一个动物遗传密码中的等位基因。
The researchers said this latest study marks the first time researchers have successfully swapped alleles in an animal's genetic code using gene editing.
BWA specifically targets low-divergent sequences- genes from a species closely related to the reference genome- in order to quickly analyze variation.
这使得他们能够评估超过3,800种化合物对与2型糖尿病相关的肝细胞中的基因表达变化的影响。
This allowed them to assess the effects of more than 3,800 compounds on gene expression changes in liver cells that are associated with type 2 diabetes.
这是由于在IGFBP2DNA序列的某些位点转移甲基,这抑制了肝脏中的基因。
This is due to the transfer of methyl groups at certain sites of the IGFBP2 DNA sequence, which inhibited the gene in the liver.
然而,它们通常包裹在细胞核中的某些蛋白质,因此DNA中的许多基因不能被解读。
They are typically wrapped around certain proteins in the nucleus and thus many genes in the DNA cannot be read as easily.
许多人在这样的调控原件中具有一些小DNA变异,这些变异影响了胰岛素生成细胞中的基因表达。
Many people have small DNA variants in such regulatory elements, and these variants affect gene expression in the cells that produce insulin.
去年,中国的一位科学家宣布,他利用CRISPR技术编辑了胚胎中的基因,并生下了一对双胞胎女孩。
Last year, a scientist in China announced that he had edited genes in embryos, using CRISPR technology, and produced twin girls.
他们必须克服的挑战之一是测量单个细胞中的基因表达可能会产生噪音。
Among the challenges that they had to overcome was the fact that measuring gene expression in single cells can be noisy.
Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit target genes in human cells.
对Wei来说,这项研究发现强调了一个观点,那就是禁用人类胚胎中的基因是一个坏主意。
To Wei, the study's findings reinforce the idea that disabling the gene in human embryos is a bad idea.
这些模型表明,HHV-6A和HHV-7基因定期打开和关闭这些大脑中的人类基因,反之亦然。
The models suggested that HHV-6A and HHV-7 genes were regularly turning on and off human genes in these brains, and vice-versa.
他们利用机器学习开发了PUR测试,从537名男性收集的样本中查看尿液中的基因表达。
The test was developed by using machine learning to analyse gene expression in post-digital rectal examination urine samples of 537 men.
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