Cats received endosulfan intravenously via a cannula at levels of 2, 3, or 4 mg/kg bw/d. At all treatment levels muscular twitching followed by convulsions was observed.
Seminiferous tubules degeneration and disruption of spermatogenesis were also reported in male rats fed 75 mg/kg body weight per day for 90 days(WHO/Europe, 2003).
The lowest no-observed effect level(NOEL), with regard to embryotoxicity and foetotoxicity for mice, rats and rabbits, was 1.0 mg/kg body weight(IPCS, 1990).
In a case in which a dose of 1000 mg/kg bw was ingested, neurological symptoms requiring anti-epileptic therapy were still required one year after exposure(JMPR 1998).
The pesticide is both acutely and chronically toxic, producing neurotoxicity, immunotoxicity, reproductive, musculoskeletal and liver toxicity at doses between 1- 10 mg/kg bw/day in experimental animal studies.
The lowest observed adverse effect level(LOAEL) for developmental neurotoxicty and liver toxicity in rodents ranged from 0.6 to 10 mg/kg body weight/day.
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