mutations occur mutating
变异
发生变异
突变
改变
发生突变 abrupt changes
的 突然 变化
的 突然 改变
事实上,表观遗传学适应可以导致发生突变 的p53基因的产生。 In fact, epigenetic adaptations can result in the production of a mutated p53 gene. 但是,如果一个DNA片段不做那么多,它就能在不引起任何损害的情况下发生突变 。 If a segment of DNA does not do much, however, it can mutate without causing any harm. Kelly和她的团队观察到典型的BRCA1蛋白保持相对稳定,但是发生突变 的BRCA1蛋白在数量上显著下降。 Kelly and her team saw that typical BRCA1 proteins remained relatively stable, but mutated BRCA1 proteins significantly reduced in number. 免疫系统能够破坏癌细胞,但有时,癌细胞能够适应和发生突变 ,从而有效地免受免疫系统破坏。 The immune system is able to destroy cancer cells, but sometimes, cancer cells can adapt and mutate , effectively hiding from the immune system. Kelly和她的团队观察到典型的BRCA1蛋白保持相对稳定,但是发生突变 的BRCA1蛋白在数量上显著下降。 The team saw that typical BRCA1 proteins remained relatively stable, but mutated BRCA1 proteins significantly reduced in number.
因为引起这种疾病的是另一个发生突变 的基因--CEP290基因。 Because the cause of the disease is another mutated gene, CEP290. 在他们的分析中,研究人员确定了七个特定基因,它们在复发疾病中极有可能发生突变 。 In their analysis, the researchers identified seven specific genes that were highly likely to be mutated in relapsed disease. 这些信号似乎会导致健康细胞发生突变 ,从而引起额外的肿瘤或癌症。 Those signals seem to inspire the healthy cells to mutate , thereby causing additional tumours or cancers.". 在此之前,人们已知FOXA1在前列腺癌中发生突变 ,但是对它的生物学功能却知之甚少。 FOXA1 was previously known to be mutated in prostate cancer, but its biological functions were poorly understood. 当基因的两个拷贝发生突变 时,就会涉及一种直接替换缺陷基因的治疗方法。 When two copies of the gene are mutated , treatment involves a more straightforward, one-step approach of simply replacing the defective gene. 基因编码p53在大约40%的癌症中发生突变 ,而其余的癌症经常会找到其他方法来激活它的功能。 The gene coding p53 is mutated in about 40 percent of all cancers, and the remaining cancers frequently find other ways to inactivate its functions. 这一信号链发生突变 ,包括Mc4r突变,可以增加肥胖的可能性。 Mutations in this signaling chain, including mutations in Mc4r, are known to increase the likelihood of obesity.如果这条信号通路中的关键蛋白发生突变 ,导致信号异常活化,就可能诱导癌症的发生。 If a key protein in this signaling pathway is mutated , causing abnormal activation of the signal, it may induce cancer. 当DNA发生突变 时,就会产生癌细胞,这些癌细胞本应被免疫系统识别为“外来物”。 Cancer cells arise when DNA is mutated , and these cells should be recognised as“foreign” by the immune system. 当其中一个发生突变 ,其他基因可以进行弥补,这样表型上观察不到发育或生理变化。 When one gene is mutated , the others can compensate leading to no observable developmental or physiological change. 在紧急情况下,例如政府发生突变 、内乱和没有事实上的政府时尤其如此。 This is particularly true during emergency situations, such as abrupt changes in Government, civil disorder and the absence of de facto authorities. 当其受体FGF3R发生突变 时,它也会导致人类侏儒症。 When its receptor FGF3R is mutated , it can also lead to dwarfism in humans. 当它们发生突变 或缺失时,就会导致基因组不稳定,这是癌症形成的一个重要因素。 When they are mutated or absent, the outcome is genomic instability, a contributory factor to cancer development. HIV发生突变 的能力一直是疫苗开发面临的一项重大挑战。 The ability of HIV to mutate has been a major challenge to vaccine development. 编码Nav1.7钠离子通道的人类基因发生突变 可导致丧失疼痛感知能力或是痛觉过敏。 Mutations in the human gene encoding the Nav1.7 sodium channel can lead to either the inability to sense pain or pain hypersensitivity.
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结果: 100 ,
时间: 0.0249
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