In a Phase 2 clinical trial conducted in Japan, GB001 showed a statistically significant improvement in time-to-first asthma exacerbation compared to placebo.
通常是在上述种种原因的作用下,出现急性发作和缓慢进展,甚至出现肾功能不全。
Usually under the above reasons, acute attacks and slow progress, and even renal insufficiency.
这些急性发作令人虚弱,可能持续数周,是造成淋巴丝虫病患者工资损失的主要原因。
These acute attacks are debilitating, may last for weeks and are the primary cause of lost wages among people suffering with lymphatic filariasis;
它通常是急性发作,持续时间少于10天,并且往往呈自限性。
It usually is of acute onset, normally lasting less than 10 days and self-limiting.
然而,急性发作期间症状会恶化,而且患者可能需要更强烈的治疗。
However, during a flare-up symptoms will worsen and the patient will probably require more intense treatment.
无论患者的疾病严重程度如何,降低急性发作风险,进而降低病情的恶化是重中之重。
Regardless of the severity of a patient's disease, reducing the risk of exacerbations and therefore a worsening of the condition is crucial.
在欧盟,Firazyr于2008年获批上市,用于C1-INH缺乏的成人患者对症治疗HAE急性发作。
Firazyr® has been approved in the European Union(EU) since 2008 for symptomatic treatment of acute attacksof HAE in adults with C1-INH deficiency.
DNA损伤和细胞分裂之间的这种延迟可能充当防止炎症急性发作的突变的防御机制。
This delay between DNA damage and cell division likely serves as a defense mechanism against mutations from acute bouts of inflammation.
Flare-ups may be triggered by changes in someone's health status, such as physical or emotional stressors, and/or by outside stimulants such as exposure to sunlight.
For most people with MS, episodes of worsening function and appearance of new symptoms, called relapses or flare-ups, are initially followed by recovery periods(remissions).
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