such mutant this mutated this alteration
这 种 改变
这 种 转变
这 种 突变
这种突变 也只影响了一种氨基酸,并且在没有心脏病的一般人群中有报道。This mutation also affected just one amino acid and has been reported in the general population without heart disease.如果你知道你有这种突变 ,与你的医生交谈,以确保你摄取足够的叶酸。 If you know you have this mutation , talk with your doctor to make sure you're getting enough folic acid. 成功登记的患者是那些表现出这种突变 或有sGBM肿瘤病史且属于正确年龄段的患者。 Successfully enrolled patients are those who display this mutation or have a history of sGBM tumors and fall within the right age bracket. 这种突变 发生在20世纪50年代的英格兰西南部,这就是为什么叫康沃尔雷克斯。This mutation happened in the 1950s in southwest England, which is why called Cornish rex.利用基因治疗理论上有可能编辑DNA,引入这种突变 来阻止HIV。 Using gene therapy, it would, in theory, be possible to edit our DNA and introduce this mutation to stop HIV.
但是确定疾病的遗传原因,使我们能够集中寻找一种方法来阻止这种突变 。 But pinpointing the genetic cause allows us to focus on finding a way to block this mutation . 当NPM1基因突变时,FOXM1不能激活额外的癌基因,因此具有这种突变 的患者往往对化疗反应更好。 When the NPM1 gene is mutated, FOXM1 can't activate additional oncogenes, so patients with this mutation tend to respond better to chemotherapy. The mutation is also more common in women and people who have never smoked. 研究人员推测,这种突变 会阻止蛋白质的产生,从而阻止这些结核菌株的存活。 The researchers presumed that this mutation would stop the protein from being produced, preventing these strains of TB from surviving. Norweigan研究人员还发现,这种突变 的两个副本的MS和佝偻病,维生素D的缺乏引起的疾病。 Norweigan researchers also found that those with two copies of this mutation had both MS and rickets, a disease caused by a vitamin D deficiency. 但首批释放的转基因按蚊不携带这种突变 ,也不打算通过它们来减少蚊子种群的数量。 But the first GM Anopheles mosquitoes released won't bear such mutations and aren't intended to cut down the population. 克莱普费尔说,有这种突变 的蛇很难在野外生存,因为两个头会经常想做“两件不同的事”。 Snakes with this mutation have difficulty surviving in the wild, partly because the two heads often want to do different things. 这种突变 可能导致危险的高浓度药物积聚在细胞中,包括在脑部。Such a mutation might cause dangerously high levels of the drug to accumulate in cells, including in the brain.这种突变 可以导致局灶性脑畸形,并且可能在其他未破解的神经系统疾病中发挥一定作用。Such mutations can cause focal brain malformations and may have a role in other unsolved neurologic diseases.起初,这种突变 的大鼠是健康的,在笼子里跑来跑去,”田说。 At first, the rats with this mutation were healthy, running around the cage,” Tian said. 他们也正在进行遗传流行病学研究,探讨这种突变 在家庭和人群中可能会导致疾病的发生。 We are also performing genetic epidemiologic studies to explore how such mutations may contribute to disease in families and in populations. 这种突变 可能是父母遗传的,也可能是怀孕期间发生了突变。These mutations can be inherited or can occur spontaneously during pregnancy.目前,这种突变 在阿拉伯按蚊体内的作用尚不清楚,而在冈比亚按蚊体内的作用则令人忧虑。 The role of this mutation in An. arabiensis is cureently unknown, and in An. gambiae is worrisome. 这种突变 可能会导致高水平药物积聚在细胞中,包括脑中。Such a mutation might cause dangerously high levels of the drug to accumulate in cells, including in the brain.我们发现,这种突变 对胰腺细胞的关键功能及其发育过程产生了间接影响。 We found that this mutation had collateral consequences on key functions of pancreatic beta cells and during their development.
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