Manipulations in mice In mouse models the researchers were able to explore directly the relationship between cigarette smoke exposure, NLRX1, and the MAVS/RIG-like helicase pathway.
因此,在小鼠模型中增加TREM2水平改善了几个让人想起在患者身上发现的特征,”Yang说。
Thus, increasing TREM2 levels in the mouse model improved several of the Alzheimer's symptoms that are similar to those found in patients,” Yang said.
许多药物,在小鼠模型中效果很好,但到目前为止,它们都在临床试验中失败了。
Many drugs work, beautifully in a mouse model, but so far they have all failed in clinical trials.
A single dose of CRISPR/Cas9 was shown to suppress the disease in a mouse model, paving the way for further exploration of CRISPR's therapeutic potential.
Using this method in mouse models, the researchers successfully inhibited melanoma and colon cancer that currently cannot be treated with CAR-T cell therapy.
In mouse models, the vaccine prompted tumors to recede, leading to a clinical trial that began enrolling HER2-positive breast cancer patients between 2012 and 2015.
在小鼠模型中,辣椒素和阿南达明都可以独立减少肠道炎症,辣椒化合物甚至可以逆转啮齿动物的1型糖尿病。
In the mouse models, both capsaicin and anandamide independently reduced gut inflammation, and the chili pepper compound even reversed type 1 diabetes in the rodents.
在小鼠模型中应用这种编辑工具后,这些研究人员寻找了脱靶突变,即在不应该发生突变的位点发生了突变。
After applying the editing tool in the mouse model, the researchers looked for non-target mutations, that is, on sites where there shouldn't be mutations.
This study demonstrated impressive efficacy of a novel statin/caffeine combination, StatC(TM) in the treatment and prevention of H5N1, H1N1 and H3N2 in a mouse model.
Remdesivir(GS-5734) effectively inhibited MERS coronavirus(MERS-CoV) replication in vitro, and showed efficacy against Severe Acute Respiratory Syndrome(SARS)-CoV in a mouse model.
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