Moreover, differentiation of neural stem cells into mature brain cells, such as neurons and star-shaped supporting cells called astrocytes, was reduced by up to 51 percent.
During fetal brain development, both neurons and astrocytes are generated from neural stem cells, which give rise to almost all cells in the cerebral cortex.
此外,神经干细胞经常强烈表达GFAP。
In addition, neural stem cells frequently strongly express GFAP.
By contrast, neither differentiated glioblastoma cells nor normal neural stem cells(from which GSCs arise8) seem to depend on the genes in this way.
这项新的研究表明,发育中的神经干细胞在不同的时间点具有特定的基因表达(转录)程序。
The new study presents evidence that developing neural stem cells are equipped with specific gene expression(transcriptional) programs at different points in time.
IGF1 is the first candidate from the NSI-532 program, a second-generation cell therapy program which combines neural stemcells with neuroprotective proteins.
从成人细胞中提取的神经干细胞被打印在3D打印指南上,并在实验室中分化为活跃的神经细胞。
Neuronal stemcells derived from adult human cells were 3-D printed on a guide and the cells differentiated into active nerve cells in the lab.
根据这项研究,当这两种关键蛋白质被劫持的胎儿神经干细胞时,脑类器官的大小平均减少了一半。
When these two key proteins are hijacked fetal neural stem cells, the size of brain organoids were, on average, halved, according to the study.
To test this hypothesis the brains of two different mouse models(3xTg-AD and Thy1-APP) were injected with genetically modified neural stem cells that over-expressed neprilysin.
Small, underdeveloped brains might easily be laid at the doorstep of destroyed neural stem cells: Fewer stem cells means fewer neurons and smaller brains.
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