Examples of using Netupitant in English and their translations into Romanian
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Ecclesiastic
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Programming
Administration of the CYP3A4 inducer rifampicin with Akynzeo alone decreased the AUC of netupitant 5.2 fold and Cmax 2.6 fold.
At a dose of 300 mg in humans, netupitant is a substrate
However, due to the large volume of distribution of palonosetron and netupitant, dialysis is unlikely to be an effective treatment for overdose.
Netupitant AUC0-∞ and Cmax increased by 1.1 fold
Netupitant doses up to 600 mg and palonosetron doses up to 6 mg have been used
Therefore, caution is recommended when netupitant is combined with digoxin
When Akynzeo is used concomitantly with another CYP3A4 inhibitor, netupitant plasma concentrations could be elevated.
When Akynzeo is used concomitantly with medicinal products that induce CYP3A4 activity, netupitant plasma concentrations could be reduced and this may result in decreased efficacy.
Exposure to netupitant(Cmax, AUC0-t
after administration of 300 mg netupitant.
substance P work: netupitant(an NK1 receptor antagonist)
based on data from two studies with intravenous netupitant, the bioavailability in humans is estimated to be greater than 60%.
The pharmacokinetics of palonosetron or netupitant has not been studied in subjects with end-stage renal disease requiring hemodialysis
Following administration of a single dose of Akynzeo, netupitant is eliminated from the body in a multi-exponential fashion,
agenesis of accessory lung lobe were observed following daily administration of netupitant in rabbits at 10 mg/kg/day
by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses.
total exposure of netupitant were increased in subjects with mild(n=8), moderate(n=8),
Co-administration of a single dose of 300 mg netupitant with a dexamethasone regimen(20 mg on Day 1, followed by 8
therefore any accumulation of netupitant or metabolites after a single dose would be negligible.
The AUC0-24(Day 1), the AUC24-36(Day 2) and the AUC84-108 and AUC84-∞(Day 4) of dexamethasone increased 2.4-fold, with co-administration of 300 mg netupitant.