Examples of using Ipscs in English and their translations into Russian
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to generate induced pluripotent stem cells iPSCs.
These protocols begin with iPSCs generated that use the traditional retroviral vectors to introduce reprogramming factors;
The iPSCs can be obtained from reprogrammed somatic tissues(fibroblasts)
in vitro strategies for cardiac generation from iPSCs, cardiac application of iPSCs, challenges confronted at present as well as perspective in the future.
Yamanaka successfully generated human iPSCs with the capacity to expand
One typical example is that iPSCs derivated from patients with heart disease differentiated into cardiomyocytes which would exhibit the specific disease behavior,
Although many studies available supported that iPSCs could be a potential substitution of ESCs
To promote the future therapeutic application of iPSCs, more effective strategies for cell delivery need developing, novel means to enhance the survival, engraft and therapeutic efficiency of transplanted cells should be explored, the long-term validation and safety after iPSCs transplantation as well as the optimized cell population need to be determined.
as 2 weeks post-MI[46], and transplanted iPSCs significantly inhibited apoptosis
Two groups separately reported that somatic cells can be successfully reprogrammed into iPSCs, marking a major landmark in stem cell research 3,4.
Further, different group demonstrated that omission of one or more of the 4 factors in some conditions was still sufficient to reprogram somatic cells into iPSCs 23,24.
The fact that human iPSCs capable of forming teratomas not only in humans
Compared to cardiomyocytes derived from iPSCs of healthy controls in the same family,
Furthermore, it seems that iPSCs derived progenies retain tumorigenic potential too 103.
IPSCs could be obtained by the cells rejuvenation of even centenarians.
A growing number of research groups have employed iPSCs to model CVDs.
In addition, the derivation of iPSCs is not repetitive.
the tumorigenicity is also an obstacle preventing the further application of iPSCs.
Disease-specific iPSCs and their derivates would exhibit at least partial phenotype of the disease.
In the study, iPSCs were differentiated as a monolayer.