Examples of using PDGFRA in English and their translations into Spanish
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encodes a protein called factor receptor alpha platelet derived growth(PDGFRA), which is part of the family tyrosine kinases RTKs.
Treatment with imatinib(Gastrointestinal stromal tumor-GIST-)- KIT and PDGFRA genes.
For GIST, patient must have PDGFRA D842V mutation and disease progression on imatinib,
Chronic eosinophilic leukemia associated with PDGFRA, also known as chronic myelomonocytic leukemia,
People with chronic eosinophilic leukemia associated with PDGFRA splenomegaly and may also have high levels of vitamin B12
Some people with associated chronic eosinophilic leukemia PDGFRA have an increased number of neutrophils or mast cells.
Chronic eosinophilic leukemia associated with PDGFRA develops as a result of mutations in the PDGFRA gene receptor alpha platelet derived growth factor.
PDGFRA signaling protein is important for the development of many types of cells throughout the body.
Chronic eosinophilic leukemia associated with PDGFRA not inherited
PDGFRA gene mutations related to GIST create a protein that no longer requires the binding of the protein growth factor, platelet derived to be activated.
Genetic alterations of the KIT gene and PDGFRA gene differ in form
Cases generated by the majority mutation in PDGFRA(50-60%), the D842V not respond to treatment with imatinib.
However, these circumstances do not explain the increase in the number of eosinophils in chronic eosinophilic leukemia associated with PDGFRA.
The fusion gene FIP1L1-PDGFRA(and other PDGFRA fusion genes) encoding a fusion protein having the function of the normal protein PDGFRA.
Similarly, point mutations in the gene PDGFRA can lead to PDGFRA protein is activated without ligand binding.
Signaling pathways stimulated control PDGFRA protein play a role in many cellular processes such as growth,
Occasionally, people with associated chronic eosinophilic leukemia PDGFRA develop other types of blood cell cancer such as acute myeloid leukemia,
The most common genetic abnormality responsible for chronic eosinophilic leukemia associated with PDGFRA, consists of a deletion of genetic material of chromosome 4, which includes a part of the gene and part of FIP1L1 PDGFRA gene FIP1 like 1-S.
Males are more likely to develop chronic eosinophilic leukemia associated with PDGFRA women, since, for unknown reasons, PDGFRA fusion genes are most frequently in males.
in IVAMI perform detection of mutations associated with chronic eosinophilic leukemia associated with PDGFRA, by complete PCR amplification of the exons of the PDGFRA and FIP1L1 genes,