Voorbeelden van het gebruik van Kras in het Engels en hun vertalingen in het Nederlands
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Programming
Progression of pre-existing pancreatic adenocarcinoma with KRAS mutation.
Preliminary data from patients with KRAS wild-type tumours showed a more pronounced beneficial effect of cetuximab on overall survival time and progression free survival time.
KRAS(Kirsten rat sarcoma 2 viral oncogene homologue) and NRAS(Neuroblastoma RAS viral oncogene homologue)
KRAS is a gene that, when mutated in tumour cells, stimulates tumour growth.
The KRAS(Kirsten rat sarcoma 2 viral oncogene homologue)
Activating mutations in the KRAS gene occur frequently in a variety human tumours
The relationship between KRAS mutation status determined in archived paraffin embedded tumour tissue
The stable disease rates in the KRAS mutant group were 12% for panitumumab
it took longer for the disease to get worse among patients with wild-type KRAS when Erbitux was added to their treatment.
The study was retrospectively analysed by wild-type KRAS(exon 2) status versus mutant KRAS(exon 2) status.
Additional mutations in KRAS and NRAS at exon 3(codon 59) were subsequently identified n 7.
OS were demonstrated in patients with KRAS wild-type tumours.
The efficacy of Vectibix was also evaluated in an open-label trial in patients with wild-type KRAS(exon 2) mCRC.
It should only be started after the presence of wild-type RAS(KRAS and NRAS genes) has been confirmed by an experienced laboratory using a validated test method.
The results of the study were analysed separately in 243 patients whose tumours contained KRAS that had not mutated and in 184 patients in whom the KRAS gene contained a mutation.
The proportion of patients with KRAS wild-type tumours from the patient population evaluable for KRAS status comprised 64.
In the KRAS wild-type population of the CALGB/SWOG 80405 study(n=1137),
including that from the EGFR activates KRAS which in turn stimulates other intracellular proteins to promote cell proliferation,
Most of the studies looked at the results separately in patients whose tumours had wild- type KRAS(one of the types of RAS genes) and patients whose tumours had mutated KRAS.
Products for Human Use(CHMP) decided that Erbitux' s benefits are greater than its risks for the treatment of patients with EGFR-expressing, KRAS wild-type metastatic.