Примери за използване на Rilpivirine на Английски и техните преводи на Български
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Rilpivirine activity is mediated by non-competitive inhibition of HIV-1 RT.
Compared to 25 mg once daily rilpivirine alone.
Significant dose dependent decreases in rilpivirine plasma concentrations are expected(induction of CYP3A).
EVOTAZ is expected to increase rilpivirine plasma concentrations.
What EDURANT contains- The active substance is rilpivirine in the form of rilpivirine hydrochloride.
Significant decreases in rilpivirine plasma concentrations are expected.
Dose dependent decreases in rilpivirine plasma concentrations are expected.
The investigators used the integrase inhibitors dolutegravir and cabotegravir and the non-nucleoside reverse transcriptase inhibitor rilpivirine to test the device in pigs.
The combination of Odefsey with these macrolide antibiotics may cause an increase in the plasma concentrations of rilpivirine(inhibition of CYP3A)
darunavir), rilpivirine exposure may increase even further and is, therefore, not recommended.
Significant decreases in rilpivirine plasma concentrations are expected(reduced absorption,
Co-administration may cause significant decreases in rilpivirine plasma concentrations(reduced absorption, increase in gastric pH).
Co-administration of EVOTAZ and rilpivirine can be used without dose adjustments,
The median duration of exposure for patients in the rilpivirine arm and efavirenz arm was 104.3 and 104.1 weeks, respectively.
As with other antiretroviral medicinal products, resistance testing should guide the use of rilpivirine(see section 5.1).
All subjects with rilpivirine RAMs also had at least 1 treatment-emergent NRTI RAM at the last post-baseline time point with genotypic data.
When rifabutin co-administration is stopped, the rilpivirine dose should be decreased to 25 mg once daily.
Of patients with virologic failure in the rilpivirine arm developed concomitant NNRTI and NRTI mutations.
Co-administration of Odefsey with medicinal products that inhibit CYP3A enzyme activity has been observed to increase rilpivirine plasma concentrations.
Administration of activated charcoal may also be used to aid in removal of unabsorbed rilpivirine hydrochloride.