They will often take it in conjunction with an aromatase inhibitor or an anti-estrogen such as Nolvadex to reduce the potential for the masculine side effects. Results vary.
The conversion of testosterone into estrogens(estriol, estrone and estradiol) is governed by the aromatase enzyme complex and occurs mainly in the liver, brain and fat tissue.
In a therapeutic setting, by blocking the aromatase enzyme, Aromasin actively prohibits the cancer from feeding off the hormone necessary to its survival.
EQ has also been found to be vulnerable to aromatization, which refers to its proclivity to convert into the estrogen hormone through contact with the aromatase enzyme.
Finally, testolone does not interact with the aromatase enzyme, so there will be no estrogenic side effects when using it as a stand-alone PED, or with other non-aromatizing compounds.
In turn, derivatives of DHT, are generally also incapable of being converted into estrogen. Anavar's disparity from the aromatase enzyme only highlights this rule.
The problem with high levels of testosterone is that“unbound” testosterone(testosterone that hasn't yet binded to the androgen receptor) can actually be converted into estrogen by the aromatase enzyme.
Taking aromatase inhibitors is a great way to maintain healthy testosterone levels during your off-season, as they prevent the aromatase enzyme from converting testosterone into estrogen.
Whereas SERMs only serve to hinder the progress of existing estrogen molecules, AIs actually stop the aromatase enzyme from being able to produce estrogen in the first place.
As a result, treatment guidelines recommend that postmenopausal women with hormone receptor-positive breast cancer consider using an aromatase inhibitor at some point in their course of treatment.[1].
Other side effects associated with the use of drugs combined in a stack, including aromatase inhibitors, anti-estrogen drugs, and those designed to protect the liver or otherwise reduce side effects also produce their own side effects.
For most athletes, a stack of one form of testosterone and either an aromatase inhibitor(AI) or a selective estrogen receptor modulator(SERM) to combat side effects will allow them to reach their goals.
Other side effects associated with the use of drugs combined in a stack, including aromatase inhibitors, anti-estrogen drugs, and those designed to protect the liver or otherwise reduce side effects also produce their own side effects.
Then we have Armidex as an aromatase inhibitor to block the action of the aromatase enzyme from converting your high testosterone levels into estrogen, and Clomid as a Selective Estrogen Receptor Modular(SERM) to block estrogen receptor activity.
Higher levels of androgen(when compared to our“normal” levels) can actually lead to a higher estrogen count in the body because of the fact that the aromatase enzyme actually converts unbound testosterone into estrogen.
Aromatase inhibitors remove only the tiny amount of estrogen that remains in the circulation of women after the menopause- but that's enough to have a substantial impact on a wide range of ER-positive tumors, despite their extraordinary differences at the molecular level.".
We hope that these data will not only encourage health care practitioners to discuss acupuncture as a complementary therapy for patients receiving aromatase inhibitors, but that they will also enhance payers' willingness to reimburse these patients for acupuncture.".
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