These include basic genetic processes that have persisted unchanged for more than three-and-a-half billion years and molecular mechanisms of animal ontogenesis that have been constant for more than one billion years.
We are now in an era where gene sequences can be obtained at low cost and high speed, and we have also established a research system to obtain genome information of tobacco genus and to investigate the molecular mechanism of grafting.
Prof. Kuroiwa has discovered the division machinery of these organelles and clarified the molecular mechanisms of organelle division which had been wrapped in mystery.
敗血症などの病気に関連することの多い炎症応答を、免疫細胞が制御する分子機構が明らかになった。
A molecular mechanism by which immune cells regulate inflammatory responses, which are often associated with diseases such as sepsis, is revealed in a report published online in Nature Immunology this week.
Our research group focuses on endoplasmic reticulum membrane ion channels, cell membrane receptors, etc., and aims to elucidate the molecular mechanisms by which cells and individuals respond to the environment.
Over the course of many years, Professor Iwasaki used fission yeast as a model system to analyze the molecular mechanism by which the Rad51 recombinase of eukaryotes2 catalyzes DNA strand exchange.
Our aim is to clarify the molecular mechanisms of these cellular responses to genotoxic and proteotoxic stresses, understanding the pathological mechanisms and developing innovative diagnostics and therapeutics.
The researchers will also study IDRs of other proteins which are involved in the onset and development of diseases and clarify their molecular structures in terms of their application to drug discovery.
The doctors subsequently elucidated the structure of CRISPR-Cas9 complex, as well as the molecular mechanisms of the cross-interaction between two types of short guide RNA and Cas9.
Some new findings have shed light on the approach to neuronal functions.(a) The first report that gangliosides might facilitate long-term potentiation, LTP, as a molecular mechanism of learning and memory was the result of Seifertユs group 1985.
Hence, we are conducting not only basic research to elucidate the molecular mechanisms that respond to the external/extracellular environment at the cell and in vivo animals, but also collaboration with medical doctors and researchers in company in order to develop new therapeutic agents.
Although it was said that the molecular mechanism by protein does not work,(1) How to divide important molecules such as DNA into two cells(2) What is the adaptive significance of using such a division method?
In subsequent studies, the molecular mechanisms of coronary vasospasm were explored thereby uncovering the role of Rho-kinase activation in both coronary artery atherosclerosis and coronary vasospasm and highlighting the benefit of Rho-kinase inhibition in the treatment of cardiovascular disease.
Aging is a big problem for humanity, and I believe that by studying bats, we can uncover the molecular mechanisms that enable mammals to achieve extraordinary longevity. If we find out what they're doing, perhaps through gene therapy, we can enable us to do the same thing.
By introducing the latest light microscopy techniques, our laboratory aims to contribute to human health enhancement and healthcare through the elucidation of the molecular mechanisms that control the intracellular machinery that drives the biological processes and development.
In our laboratory, we are interested in the molecular mechanism of the phenomenon of cell regeneration from cell contents. We have successfully identified compounds that play a key role in the phenomenon and are now working to completely elucidate the molecular mechanisms.
These dueling qualities make the p53 protein and the gene that makes it among the most studied in biology, yet the molecular mechanisms that govern its stability and function have yet to be fully understood.
These dueling qualities make the p53 protein and the gene that codes for it among the most studied in biology, yet the molecular mechanisms that govern its stability and function have yet to be fully understood.
These results illustrate how an understanding of the molecular machinery inside a cancer cell can lead to new therapies which can kill tumor cells while sparing normal cells, thus greatly reducing toxicities for patients,” said Staudt.
Through a series of basic and clinical researches, we discovered in 2000 for the first time in the world a molecular mechanism of coronary spasm in which the expression and activity of a protein kinase*6 called Rho-kinase*5, which served as the molecular switch for the vascular smooth muscle, were increased.
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