There is no evidence supporting a survival benefit for patients with advanced HCC receiving systemic cytotoxic chemotherapy when compared with no treatment or best supportive care.
They identified several genes essential to venom cell toxicity, including those involved in cholesterol biosynthesis, and showed that interfering with these genes increased resistance to box jellyfish toxin.
This regimen may be useful as an alternative for patients who do not require cytotoxic chemotherapy or whose disease has progressed on conventional therapy,” the researchers wrote.
Investigators at the University of Texas MD Anderson Cancer Center used an ATO-based regimen, which included gemtuzumab ozogamicin(GO) as the only cytotoxic drug.
In some cases, monoclonal antibodies are conjugated to radio-isotopes or toxins to allow specific delivery of these cytotoxic agents to the intended cancer cell target.
In patients with single anti-HBc positive patients, the levels of HBsAg, HBV DNA and ALT should be closely monitored when using immunosuppressive agents or cytotoxic drugs.
Synergy can be in terms of lower cytotoxicity, increased anti-proliferative and/or anti-infective effect, or some other beneficial effect of the combination compared with the individual components.
Not all of these methods can be applied to all types of cells and experimental applications, and there is a wide variation amongst them with respect to transfection efficiency, cell toxicity, effects on normal physiology, and level of gene expression.
前の細胞毒性または放射線療法,高齢者や子供の年齢。
prior cytotoxic or radiation therapy, the elderly and children's age.
The use of the cytotoxic and other anticancer agents described above in chemotherapeutic regimens is generally well characterized in the cancer therapy arts, and their use herein falls under the same considerations for monitoring tolerance and effectiveness and for controlling administration routes and dosages, with some adjustments.
All compounds in the Malaria Box have been screened in vitro against 3D7(chloroquine(CQ) sensitive but sulfadoxine resistant strain of P. falciparum) and cytotoxicity assays were performed on human embryonic kidney cell lines(HEK-293).
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