Oct4 and its cofactor Sox2 are at the center of a collection of transcription factors that control the first decisions in the development of an embryo.
Using mouse embryos at stages just prior to E3.5 and E4.5, the team first searched for a gene regulating Lefty1 expression, and identified transcription factor Foxh1, a transcription factor of Nodal signaling, as a direct regulator of Lefty1 expression.
The largest subset of pediatric supratentorial(ST) ependymomas are characterized by gene fusions involving RELA,[9][10] a transcriptional factor important in NF-κB pathway activity.
Such factors then recruit general transcription factors, Mediators, RNA polymerases, nucleosome remodellers, and histone modifiers, most of which are large protein complexes of 1-3 MDa in size.
Integbio Database Catalog- Integbio Database Catalog Laboratory of Developmental Biology, Graduate School of Science, Osaka University REGULATOR is a metazoan transcription factor(TF) and maternal factor resource, specifically designed for developmental biology studies.
Some of these transcription factors act to reduce the levels of components needed for T-cell movement, causing movement to be slowed and prolonging the interaction with dendritic cells.
Noncoding regions under very strong negative selection included binding sites of some chromatin and general transcription factors(TFs) and core motifs of some important TF families.
The phosphorylated STAT1 and STAT2 combine with IFN-regulatory factor 9(IRF-9) to form IFN-stimulated regulatory factor 3(ISGF-3) transcription factor complex that translocates to the nucleus.
For instance, scientists know little about many of the C2H2 ZF transcription factors highlighted in this study: which cell types they are active in, which genes they affect, which cancers may depend on them.
The phosphorylated STAT1 and STAT2 complex with IFN-regulatory factor 9(IRF-9) to form the IFN-stimulated regulatory factor 3(ISGF-3) transcription factor complex that is translocated to the nucleus.
Substrate utilization is governed by a host of factors(i.e., hormonal secretions, enzyme activity, transcription factors, etc.), and these factors can change by the moment.
Studies have found that resveratrol is capable of inhibiting inflammatory enzymes, and may also be able to inhibit substances called pro-inflammatory transcription factors.
Additional members of the nuclear receptor family of proteins, known as transcriptional factors(such as DHR38 or betaFTZ-1), may also be ligand dependent or independent partners for EcR, USP, and/or RXR.
The compound that joined the dots between gray hair and the immune system was transcription factor MITF, which is a protein that regulates much of the cellular activity within melanocytes.
When the normal cells are exposed to such an environment, the α-chain of a transcription factor, hypoxia inducible factor(HIF), which is usually rapidly degraded in proteasome in the cytoplasm under normoxic conditions, undergoes a nuclear transition.
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