Their research has revealed that IL-6 is the representative molecule of inflammatory cytokines and their findings have founded a conceptual basis for explaining pathology of many refractory diseases from the roles of a specific cytokine.
The use of antiseptics for intractable intractable ulcers is controversial, but if the protracted healing factor is clearly infection, the use of antiseptics is still essential.
A majority of patients with advanced incurable cancers who have an MSI-high tumor should be given the option to be treated with immunotherapy," she said.
The Center plans on becoming the pedestal for world class research on cardiovascular, blood and liver related intractable diseases. In order to achieve this goal, basic research, clinical research and translational research is being conducted and promoted at the Center.
As our first oncology treatment approved in Japan, we are proud to provide a much needed innovative treatment option for adults and children with relapsed or refractory B-cell ALL, one of the most aggressive B-cell malignancies.
Strong Fields Treatment of intractable osteoarthropathy of the upper limbs, paralysis due to a peripheral nerve disorder, hand reconstruction and treatment of pain, contracture removal and musculoskeletal reconstruction for contracted hands, treatment of circulatory disorders of the upper limbs, minimally invasive surgery for small joint disorders, congenital anomaly, and functional reconstruction of hands.
In an open-label phase II study of sunitinib in adult patients with refractory thymic carcinoma, partial responses were observed in 26% of patients with thymic carcinoma and stable disease was achieved in 65% of patients with thymic carcinoma.[100].
As described above, there are various types of nucleic acid drug, and it is possible to target in vivo molecules such as DNA, RNA and protein. Therefore, nucleic acid drug leads to the development of a specific drug for intractable diseases that are difficult to treat with existing methods.
Overview of research results A refractory cutaneous ulcer is a condition in which a wound which would normally heal becomes refractory because of infection, angiopathy, etc., and remains unhealed for several months to several years, accompanied by severe pain.
By delivering mRNA to the necessary place at the necessary time to produce proteins that would improve and/or restore the functions of motor and sensory cells, definitive treatment will be actualized against intractable diseases, such as central nervous system disorders and age-related motor and sensory disorders.
Long-term follow-up data presented from the Phase II ACE-LY-004 trial in relapsed or refractory MCL showed sustained and clinically meaningful responses to CALQUENCE with a median follow-up of more than two years(26 months), confirming its efficacy and safety profile in this patient population.
In an open-label phase II study of sunitinib in adult patients with refractory thymoma, partial responses were observed in 6% of patients with thymoma, and stable disease was achieved in 75% of patients with thymoma.[14].
We are conducting the above-mentioned studies that are directly applicable to clinical practice not only to elucidate the pathology of intractable skin diseases, but also to develop new therapeutic strategies and diagnostic methods for these diseases based on results of the studies.
Integbio Database Catalog- Integbio Database Catalog The RADDAR-J site was constructed for consolidating and supporting registry studies about intractable diseases covered by the Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development(AMED) and the Research Project on Rare/Intractable Disease of the Ministry of Health, Labour and Welfare MHLW.
Although he most frequently treats thyroid cancer in its early stages, he also performs surgeries(incl. tracheotomy, esophagotomy, and thoracotomy) for refractory thyroid cancer that has spread to the airway, throat, and mediastinum more than anyone else at home and abroad and exhibits the highest cure rate.
Strong Fields High-precision image-guided navigation surgery for brain tum ors, super advanced endovascular surgery and aneurysmal clipping for stroke, surgery for pituitary tumor and intraventricular surgery using neuroendoscope, stereotactic surgery for Parkinson's disease and essential tremor based on functional neurosurgery, surgery for intractable pain and epilepsy surgery, minimally invasive surgery for spinal diseases and pediatrics, and development of advanced medical care including nucleicacid technology by the advanced neurosurgery development group.
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