Despite decades of effort, scientists still don't understand how biology achieves this protein-folding process, or, once folded, how protein structures are stabilised.
最早的线索是一些蛋白质片段没有显示在X射线晶体学或NMR研究中,这些是研究蛋白质结构的标准方法。
The earliest clue was that some protein segments didn't show up in X-ray crystallography or NMR studies, the standard ways of studying protein structure.
这项名为MicroED的技术是五年前开发的用于研究蛋白质结构的技术。
Known as microcrystal-electron diffraction(MicroED), this technique was developed 5 years ago to study protein structures.
锌是一种矿物质,有助于维持视网膜、细胞膜和眼睛蛋白质结构的健康。
Zinc is a mineral that helps maintain the health of the retina, cell membranes, and protein structure of the eye.
温度升高会干扰神经细胞之间的通讯,因为高温会影响DNA和蛋白质结构以及细胞膜的完整性。
Increased temperatures disturb communication between nerve cells, as the heat affects DNA and protein structure as well as cellular membrane integrity.
微光束和光栅化软件是打开这种新型蛋白质结构大门的关键工具。
The minibeam and rastering software were key tools that opened the door to this new class of protein structures.”.
虽然有100多万个已知的蛋白质序列,但现在还只有少量的蛋白质结构序列经过实验测定。
While there are over a million known protein sequences, only a limited number of protein structures are experimentally determined.
进一步研究蛋白质结构的3D建模显示这些插入物存在于2019-nCoV的结合位点。
D modelling of the protein structure displayed that these insertions are present at the binding site of 2019-nCoV.
这一步骤有助于模型更好地明确氨基酸在蛋白质结构中的确切位置,从而进一步了解每个氨基酸的功能。
This helps the model better learn where exactly amino acids fall in a protein's structure, which further updates each amino acid's function.
混合后不同时间测定蛋白质结构可以组装成延时序列,显示生物学的分子基础。
Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
预测蛋白质结构,对于生物学研究有着深刻的理论和实际意义。
Prediction of protein structures has profound theoretical and practical influence over biological study.
预测蛋白质结构使我们能够洞察其在这些特性的生物化学方面所起的作用。
Predicting the structure of proteins can provide insight into the roles they play in the biochemistry of these traits.
然后,它使用了新方法来尝试预测蛋白质结构,并搜索与其预测相匹配的已知结构。
It then used new methods to try to construct predictions of protein structures, searching known structures that matched its predictions.
DNA结构揭示基因是如何工作的,蛋白质结构揭示酶是如何工作的。
The structure of DNA revealed how genes work, and the structure of proteins revealed how enzymes function.
这有助于模型更好地了解氨基酸在蛋白质结构中的确切位置,从而进一步更新每种氨基酸的功能。
This helps the model better learn where exactly amino acids fall in a protein's structure, which further updates each amino acid's function.
These and other computational tools from his group have enabled numerous discoveries related to protein molecular recognition, protein-membrane interactions, and protein structural stability.
These include applications for the analysis of cellular regulatory networks, protein structure, DNA and protein sequences, gene expression, and other kinds of biological data.
Some enzyme activities are determined only by their protein structures, while some enzymes need one or many non-protein components, known as the auxiliary factor.
在发育生物学,蛋白质结构与功能,分子遗传学,营养,代谢,酶学,多核心问题,称霸深入的研究环境。
Central problems in developmental biology, protein structure and function, molecular genetics, nutrition, metabolism, enzymology, and more, dominate the intense research environment.
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