In SARS-CoV, the RBD is in the 318th to 510th amino acids on the S1 fragment, which binds to the human ACE2 as well as its coreceptors for viral entry.
The RBD of SARS-CoV is capable of recognizing the ACE2 receptors of various animals, including bat, civet, mouse and raccoon dog, allowing interspecies transmission of the virus.
Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019.
SARS, also known as“atypical pneumonia”, was the first well documented HCoV-caused pandemic in human history and the etiological agent is SARS-CoV, the third HCoV discovered.
Whereas a bat beta-CoV sharing 95% nucleotide homology with SARS-CoV has been found, there also exists a bat-CoV sharing 96% nucleotide homology with SARS-CoV-2.
An earlier study reported that the R0 of SARS-CoV-2 was as high as 6.47 with a 95% confidence interval(CI) of 5.71-7.23, whereas the R0 of SARS-CoV only ranged from 2 to 4.
这种病毒被正式命名为SARS冠状病毒(SARS-CoV)。
The virus was officially named the SARS coronavirus(SARS-CoV).
它们之间几乎完全相同,共有79.5%的序列识别到SARS-CoV。
They are almost identical to each other and share 79.5% sequence identify to SARS-CoV.
论文指出,MERS-CoV和SARS-CoV也被发现感染男性多于女性。
MERS-CoV and SARS-CoV have also been found to infect more males than females.
SARS-CoV-2具有与SARS-CoV/MERS-CoV和4种社区获得性HCoV相似的特征。
SARS-CoV-2 has features that are similar to both SARS-CoV/MERS-CoV and the four community-acquired HCoVs.
SARS-CoV似乎是由于与猫和单峰骆驼的MERS接触引起的。
SARS-CoV appears to have been caused via contact with civet cats, and MERS from dromedary camels.
关系最密切的蝙蝠冠状病毒和SARS-CoV在1986年发生了分化。
The most closely related bat coronavirus and SARS-CoV diverged in 1986.
这部分解释了为什么SARS-CoV-2的传播远远比SARS-CoV更加迅速和广泛。
This partially explains why SARS-CoV-2 spread much faster and broader than SARS-CoV.
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