STATINA - prijevod na Engleskom

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• statins

Primjeri korištenja Statina na Hrvatski i njihovi prijevodi na Engleskom

bez zatajenja bubrega pri primjeni lijekova za snižavanje lipida poput fibrata i statina.
has been reported with administration of lipid-lowering substances like fibrates and statins.

Stoga se preporučuje oprez pri istovremenoj primjeni dabrafeniba i OATP1B1 ili OATP1B3 supstrata poput statina.
Therefore caution is recommended at co-administration of dabrafenib and OATP1B1 or OATP1B3 substrates such as statins.

Klinički podaci upućuju na to da farmakokinetika statina uglavnom nije promijenjena pri istvremenoj j primjeni s takrolimusom.
Clinical data suggest that the pharmacokinetics of statins are largely unaltered by the co-administration of tacrolimus.

Sudeći prema kliničkim podacima, farmakokinetika statina uglavnom nije promijenjena pri istodobnoj primjeni takrolimusa.
Clinical data suggest that the pharmacokinetics of statins are largely unaltered by the co-administration of tacrolimus.

niže doze održavanja statina, a bolesnike treba nadzirati
maintenance doses of statins should be considered

Dva ispitivana statina(simvastatin i pravastatin)
Two of the statins, simvastatin and pravastatin,

Doziranje statina i ezetimiba treba biti u skladu s uputama za pojedini navedeni lijek.
The dosing of the statin and the ezetimibe should follow the instructions for that particular medicine.

Budući da je korist statina u smanjenu vaskularnog rizika puno veća od rizika razvoja dijabetesa, ovo ne treba biti razlog za prekid liječenja statinima.
This risk, however, is outweighed by the reduction in vascular risk with statins and therefore should not be a reason for stopping statin treatment.

Ova dva multicentrična, placebom kontrolirana, dvostruko slijepa, 18-mjesečna ispitivanja uključivala su 732 bolesnika s heterozigotnom obiteljskom hiperkolesterolemijom koji su primali maksimalnu podnošljivu dozu statina, uz dodatnu terapiju koja modificira lipide ili bez nje.
Two multicenter, placebo-controlled, double-blind 18-month studies included 732 patients with heFH receiving a maximally tolerated dose of statin, with or without other lipid-modifying therapy.

Ako se statini primjenjuju istodobno s eltrombopagom, treba razmotriti smanjenje doze statina uz praćenje eventualne pojave nuspojava statina vidjeti dio 5.2.
When co-administered with eltrombopag, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken see section 5.2.

Kad se primjenjuju istovremeno s lijekom Harvoni, potrebno je razmotriti sniženu dozu statina i provoditi pažljivo praćenje zbog nuspojava statina vidjeti dio 4.4.
When co-administered with Harvoni, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken see section 4.4.

Od transportnih proteina preporučuje se genotipizacija SLCO1B1 za bolju prevenciju nuspojava pri primjeni statina.
One of transport proteins recommended for genotyping is SLCO1B1 for better prevention of side eff ects in the use of statins.

Lijekovima koji snizuju vrijednosti kolesterola, ako maksimalna doza statina ne uspije dovoljno sniziti vrijednosti kolesterola.
Lowering medicines, if the maximum dose of a statin does not lower levels of cholesterol sufficiently.

zbog povećane koncentracije statina može dovesti do razvoja miopatije, uključeno.
because increasing concentrations of statins can lead to the development of myopathies, incl.

može značajno povećati koncentraciju statina, što povećava rizik od miopatije
can significantly increase the concentration of the statin, which increases the risk of myopathy

U kliničkim ispitivanjima nije bilo dokaza koji bi ukazivali na probleme sa sigurnošću primjene kod istodobne primjene dronedarona i statina koji se metaboliziraju pomoću CYP3A4.
In clinical trials, there was no evidence of safety concerns when dronedarone was co-administered with statins metabolised by CYP 3A4.

Bolesnike koji primaju Lojuxtu kao adjunktivnu terapiju statinu treba nadzirati zbog nuspojava povezanih s primjenom visokih doza statina.
Patients receiving Lojuxta as adjunctive therapy to a statin should be monitored for adverse events that are associated with the use of high doses of statins.

Stoga je Praluent odobren za primjenu u bolesnika koji ne odgovaraju primjereno na maksimalnu podnošljivu dozu statina ili koji ne podnose statine..
Therefore, Praluent has been approved for use in patients who do not adequately respond to the maximum tolerated dose of statins or who cannot be given statins..

Slučajevi miopatije/rabdomiolize povezani su s istodobnom primjenom statina i niacina(nikotinske kiseline)
Cases of myopathy/rhabdomyolysis have been associated with concomitant administration of statins and niacin(nicotinic acid)

U bolesnika s heterozigotnom obiteljskom hiperkolesterolemijom na visokim dozama statina, sistemska izloženost evolokumabu je bila nešto manja nego u ispitanika na niskim do umjerenim dozama statina omjer AUClast 0, 74 90% CI 0, 29; 1, 9.
In patients with heterozygous familial hypercholesterolemia(HeFH) on high dose statin, the systemic exposure of evolocumab was slightly lower than in subjects on low-to-moderate dose statin the ratio of AUClast 0.74 90%CI 0.29; 1.9.