PREGABALIN in English translation

• pregabalin

Examples of using Pregabalin in Danish and their translations into English

Pregabalin er undersøgt i 3 kontrollerede studier af 12 ugers varighed med dosering enten 2 eller 3 gange dagligt.
Pregabalin has been studied in 3 controlled clinical studies of 12 week duration with either twice a day dosing(BID) or three times a day(TID) dosing.

Det aktive indholdsstof, pregabalin, er en gamma- aminosmørsyre analog(S)- 3-(aminomethyl)- 5- methylhexansyre.
The active substance, pregabalin, is a gamma-aminobutyric acid analogue(S)-3-(aminomethyl)-5- methylhexanoic acid.

relation til varighed og dosering af pregabalin i forbindelse med seponering af langtidsbehandling med pregabalin.
severity of withdrawal symptoms in relation to duration of use and dosage of pregabalin.

Det N- methylerede derivat af pregabalin, der er pregabalins hovedmetabolit, genfindes i urin
The N- methylated derivative of pregabalin, the major metabolite of pregabalin found in urine,

Sikkerheden og virkningen hos børn og unge(under 18 år) er ikke undersøgt, og derfor bør pregabalin ikke anvendes til denne aldersgruppe.
The safety and efficacy in children and adolescents(under 18 years of age) has not been established and therefore, pregabalin should not be used in this age group.

Når De stopper med at tage pregabalin efter langtidsbehandling eller korttidsbehandling, har De brug for at vide, at De måske oplever visse bivirkninger.
After stopping long and short-term pregabalin treatment, you need to know that you may experience certain side effects.

En øget hyppighed af nethindeatrofi ses sædvanligvis hos ældre albinorotter efter langtidseksponering med pregabalin ved doser ≥5 gange den maksimale anbefalede gennemsnitlige humane dosis.
An increased incidence of retinal atrophy commonly observed in aged albino rats was seen after long term exposure to pregabalin at exposures≥ 5 times the mean human exposure at the maximum recommended clinical dose.

Pregabalin absorberes hurtigt, når det gives fastende, og maksimal plasmakoncentration nås
Pregabalin is rapidly absorbed when administered in the fasted state,

Pregabalin bindes til en hjælpeundergruppe(α2- δ protein)
Pregabalin binds to an auxiliary subunit(α2-δ protein)

I præ- natale/ post- natale toksicitetsundersøgelser fremkalder pregabalin udviklingstoksicitet hos afkom af rotter ved doser> 2 gange den maksimale anbefalede humane dosis.
Pregabalin induced offspring developmental toxicity in rats at exposures> 2 times the maximum recommended human exposure.

Ved tillægsbehandling med pregabalin, er der ikke tilstrækkelig dokumentation for at seponere samtidig brug af anden antiepileptika,
There are insufficient data for the withdrawal of concomitant antiepileptic medicinal products, once seizure control with pregabalin in the add-on situation has been reached,

Følgelig har in- vivo forsøg ikke vist klinisk relevante farmakokinetiske interaktioner mellem pregabalin og phenytoin, carbamazepin,
Accordingly, in in vivo studies no clinically relevant pharmacokinetic interactions were observed between pregabalin and phenytoin, carbamazepine,

I de kontrollerede forsøg udgik 13% af patienterne, der fik pregabalin, og 7% af patienterne, der fik placebo, på grund af bivirkninger.
In all controlled studies, the discontinuation rate due to adverse reactions was 13% for patients receiving pregabalin and 7% for patients receiving placebo.

Hvis De har taget pregabalin i længere tid, er det på nuværende tidspunkt ikke klartlagt, om disse symptomer forekommer oftere eller i en sværere grad.
It is not clear at this time whether these symptoms occur more commonly or severely if you have been taking pregabalin for a longer period of time.

ses en sådan forbedring hos 33% af patienterne behandlet med pregabalin og hos 18% af patienterne behandlet med placebo.
such an improvement was observed in 33% of patients treated with pregabalin and 1 8% of patients on placebo.

Det aktive stof i Lyrica, pregabalin, ligner i sin struktur kroppens egen"neurotransmitter"(signalstof) GABA(gamma- aminosmørsyre), men dets biologiske virkninger er meget anderledes.
The active substance in Lyrica, pregabalin, is similar in structure to the body' s own‘ neurotransmitter' GABA(gamma-amino butyric acid), but has very different biological effects.

Da pregabalin ikke undergår signifikant metabolisme
Since pregabalin does not undergo significant metabolism

Pregabalin er undersøgt i 10 kontrollerede kliniske studier i op til 13 uger med dosering 2 gange dagligt, og i op til 8 uger
Pregabalin has been studied in 10 controlled clinical studies of up to 13 weeks with twice a day dosing(BID)

lamotrigin, pregabalin) samt hos patienter i behandling med klasse I- antiarytmetika.
lamotrigine, pregabalin) and in patients treated with class I antiarrhythmic drugs.

Pregabalin er undersøgt i 6 kontrollerede studier af 4- 6 ugers varighed, et studie med ældre af 8 ugers varighed
Pregabalin has been studied in 6 controlled studies of 4-6 week duration,