Examples of using Azacitidine in English and their translations into Danish
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One case of overdose with azacitidine was reported during clinical trials.
No formal clinical drug interaction studies with azacitidine have been conducted.
Pregnancy There are no adequate data on the use of azacitidine in pregnant women.
AZA azacitidine; CCR conventional care regimens;
The active substance in Vidaza, azacitidine, is a medicine belongs to the group‘ anti-metabolites.
Azacitidine plus best supportive care(BSC)(n 179) was compared to conventional care regimens CCR.
permanent discontinuation of azacitidine, or reduction of azacitidine dose in the pivotal study.
If reconst ituted azacitidine comes into contact with the skin, immediately and thoroughly wash with soap and water.
Azacitidine induced tumours of the haematopoietic system in female mice,
The table below contains the adverse reactions for which a causal relationship with azacitidine treatment could reasonably be established.
Excretion Azacitidine is cleared rapidly from plasma with a mean elimination half-life(t½) after subcutaneous administration of 41± 8 minutes.
Vidaza should not be used in people who may be hypersensitive(allergic) to azacitidine or any of the other ingredients.
Azacitidine is an analogue of cytidine,
Absorption Azacitidine was rapidly absorbed after subcutaneous administration with peak plasma azacitidine concentrations of 750± 403 ng/ ml occurring at 0.5 h(the first sampling point) after dosing.
After reconstitution with 4 ml of water for injections, the reconstituted suspension contains 25 mg/ml azacitidine.• The other ingredient is mannitol E421.
skin was seen in mice treated with azacitidine administered intraperitoneally for 50 weeks.
Mechanism of action Azacitidine is believed to exert its antineoplastic effects by multiple mechanisms including cytotoxicity on abnormal haematopoietic cells in the bone marrow and hypomethylation of DNA.
Administration of azacitidine to male mice prior to mating with untreated female mice resulted in decreased fertility
death were reported rarely in patients treated with intravenous azacitidine in combination with other chemotherapeutic agents.
The most commonly reported adverse reactions with azacitidine treatment were haematological reactions(71.4%)
