Examples of using Repaglinide in English and their translations into Danish
{-}
-
Medicine
-
Colloquial
-
Official
-
Financial
-
Ecclesiastic
-
Official/political
-
Computer
an inhibitor of CYP2C8, and repaglinide(a single dose of 0.25 mg)
Repaglinide pharmacokinetics are characterised by a mean absolute bioavailability of 63%(CV 11%),
increased repaglinide AUC and Cmax about 2.5-fold and 1.8-fold respectively.
slightly increased the repaglinide(AUC) by 1.4-fold
dose of 0.5 mg, increased repaglinide AUC and C max about 2.3-fold(90% CI[2.03-2.63]) and 1.6-fold 90% CI.
No interaction was observed when Cholestagel was administered one hour after repaglinide.
Clinical study results have shown that repaglinide is optimally dosed in relation to main meals preprandial dosing.
For that reason repaglinide should be avoided during pregnancy
Repaglinide is almost completely metabolised,
3A4 are co- administered simultaneously with repaglinide.
or simvastatin with repaglinide, all CYP3A4 substrates, did not significantly alter the pharmacokinetic parameters of repaglinide. .
Based on the experience with repaglinide and with other hypoglycaemic agents the following adverse events have been seen.
Specific patient groups Repaglinide is primarily excreted via the bile
At such times, it may be necessary to discontinue repaglinide and treat with insulin on a temporary basis.
Repaglinide closes ATP-dependent potassium channels in the β-cell membrane via a target protein different from other secretagogues.
hypoglycaemic unconsciousness As with other hypoglycaemic agents, hypoglycaemic reactions have been observed after administration of repaglinide.
the concomitant use of ciclosporin with repaglinide should be avoided.
Repaglinide is rapidly absorbed from the gastrointestinal tract,
Repaglinide is also indicated in combination with metformin in type 2 diabetes patients who are not satisfactorily controlled on metformin alone.
inhibitor of the metabolism of repaglinide.