Examples of using Tolcapone in English and their translations into Dutch
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Medicine
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Colloquial
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Official
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Computer
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Programming
The Community marketing authorisation for Tasmar(tolcapone), originally authorised for adjunctive treatment of Parkinson' s disease,
The highest dose of tolcapone administered to humans was 800 mg three times daily,
100 mg tid and 200 mg tid of tolcapone respectively.
Benserazide interaction: Due to the interaction between high dose benserazide and tolcapone(resulting in increased levels of benserazide),
Tolcapone' s effect on levodopa pharmacokinetics is similar with all pharmaceutical formulations of levodopa/ benserazide
The main metabolic pathway of tolcapone is conjugation to its inactive glucuronide.
should be swallowed whole because tolcapone has a bitter taste.
Since tolcapone interferes with the metabolism of catecholamines,
200 mg(yellow-orange) of tolcapone.
Tolcapone and its metabolites are yellow
Tolcapone is a low-extraction-ratio drug(extraction ratio 0.15),
Tolcapone, when administered alone,
Tolcapone did not change the pharmacokinetics of desipramine,
A study in patients with hepatic impairment has shown that moderate non-cirrhotic liver disease had no impact on the pharmacokinetics of tolcapone.
Drugs that increase catecholamines: Since tolcapone interferes with the metabolism of catecholamines,
Since clinical information is limited regarding the combination of warfarin and tolcapone, coagulation parameters should be monitored when these drugs are co-administered.
decreases the absorption of tolcapone, but the relative bioavailability of a dose of tolcapone taken with a meal is still 80% to 90.
Urine discolouration: Tolcapone and its metabolites are yellow
Since clinical information is limited regarding the combination of warfarin and tolcapone, coagulation parameters should be monitored when these drugs are co-administered.
Tolcapone is almost completely metabolised prior to excretion,