Examples of using Dextromethorphan in English and their translations into Polish
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ketamine or dextromethorphan should be avoided.
Therefore, in view of the MAO inhibitory activity of rasagiline the concomitant administration of rasagiline and dextromethorphan is not recommended see section 4.4.
it is unknown whether dextromethorphan is excreted in human milk.
produced a 3-fold increase in plasma concentrations of dextromethorphan CYP2D6 substrate.
phenothiazines, dextromethorphan and atomoxetine.
In the presence of quinidine, CYP3A4-dependent oxidative metabolism is believed to play a greater role in dextromethorphan elimination.
Two additional phase III studies were conducted using a higher dose combination of dextromethorphan 23 mg/quinidine 26 mg.
Metabolism of dextromethorphan is inhibited by quinidine, such that adverse reactions of overdose due to NUEDEXTA might be more severe or more persistent compared to overdose of dextromethorphan alone.
The quinidine component of NUEDEXTA serves to selectively inhibit CYP2D6-dependent oxidative metabolism of dextromethorphan, thus increasing dextromethorphan plasma concentrations.
produced a 3-fold increase in plasma concentrations of dextromethorphan CYP2D6 substrate.
Dextromethorphan is a low-affinity uncompetitive NMDA antagonist and sigma-1 receptor agonist
Due to the possibility of dextromethorphan abuse, physicians should evaluate patients for a history of drug abuse,
pup weight were slightly decreased from the lowest dose corresponding approximately to 1and 50 times the human dose of 30/18 mg/kg on a mg/m2 basis, for dextromethorphan hydrobromide and quinidine sulfate, respectively.
Based on the results of transporter inhibition studies drug-drug interactions related to dextromethorphan inhibition of P-gp, OATP1B1, OATP1B3, OCT2, OAT1, OAT3 or BSEP are not expected during treatment withNUEDEXTA.
In a study of a combination dose of dextromethorphan 23 mg/ quinidine 26 mg twice daily in 12 subjects with mild or moderate hepatic impairment(as indicated by the Child-Pugh method; 6 each) compared to 9 healthy subjects(matched in gender, age, and weight range to impaired subjects), subjects with moderate hepatic impairment showed similar dextromethorphan AUC and Cmax and clearance compared to healthy subjects.
Dextromethorphan. As in cough syrup?
Dextromethorphan. As in cough syrup?
Nuedexta is available as capsules(15 mg or 23 mg dextromethorphan and 9 mg quinidine)
Dextromethorphan may increase the risk of serotonin syndrome,
also using the higher dose combination of dextromethorphan 23 mg/quinidine 26 mg,