Examples of using Dextromethorphan in English and their translations into Swedish
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Dextromethorphan has been shown to be a mild/moderate inhibitor of the OCT1 transporter in vitro.
The role of quinidine is to prevent dextromethorphan from being broken down early in the body and thereby it prolongs the action of dextromethorphan in the body.
Dextromethorphan is rapidly metabolized by CYP2D6 to its primary metabolite,
The quinidine component of NUEDEXTA serves to selectively inhibit CYP2D6-dependent oxidative metabolism of dextromethorphan, thus increasing dextromethorphan plasma concentrations.
Dextromethorphan may increase the risk of serotonin syndrome see Warnings
Dextromethorphan may increase the risk of serotonin syndrome,
Dextromethorphan- cough medicine atomoxetine- used to treat attention deficit hyperactivity disorder(ADHD)
Two additional phase III studies were conducted using a higher dose combination of dextromethorphan 23 mg/quinidine 26 mg.
also using the higher dose combination of dextromethorphan 23 mg/quinidine 26 mg,
After administration of the combination product, protein binding remains essentially the same as that after administration of the individual components; dextromethorphan is approximately 60-70% protein bound,
neurotransmitters are involved in the control of emotions, dextromethorphan helps to normalise its activity in the brain,
In a study of a combination dose of dextromethorphan 23 mg/ quinidine 26 mg twice daily in 12 subjects with mild or moderate hepatic impairment(as indicated by the Child-Pugh method; 6 each) compared to 9 healthy subjects(matched in gender, age, and weight range to impaired subjects), subjects with moderate hepatic impairment showed similar dextromethorphan AUC and Cmax and clearance compared to healthy subjects.
In a study of a combination dose of dextromethorphan 23 mg/ quinidine 26 mg twice daily in 12 subjects with mild(CLCR 50-80 mL/min) or moderate(CLCR 30-50 mL/min) renal impairment(6 each) compared to 9 healthy subjects(matched in gender, age, and weight range to impaired subjects), subjects showed little difference in quinidine or dextromethorphan pharmacokinetics compared to healthy subjects.
Studies with Higher Dose Combinations of dextromethorphan/ quinidine.
A medicine used to relieve cough(dextromethorphan).
NUEDEXTA 15 mg/9 mg hard capsules dextromethorphan/ quinidine.
It's got dextromethorphan. No!
No! It's got dextromethorphan.
Dextromethorphan is a sigma-1 receptor agonist and an uncompetitive NMDA receptor antagonist.
Dextromethorphan/ quinidine has not been studied in patients with severe renal impairment.