Examples of using Accelerated phase in English and their translations into Portuguese
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intolerant CML patients in chronic and accelerated phase, the change from baseline in mean time-averaged QTcF interval at steady state was 6
these patients may experience disease progression to the accelerated phase and blast crisis.
mutations are associated with increases in transformation to the accelerated phase 32% and blast crisis 16%,
of chronic-phase CML patients, the time from the beginning of imatinib treatment to the progression of the disease to the accelerated phase or blast crisis is shorter in patients with mutations than those without mutations.
Tasigna is indicated for the treatment of adults with chronic phase and accelerated phase Philadelphia chromosome positive chronic myelogenous leukaemia(CML) with resistance or intolerance to prior therapy including imatinib.
12% in accelerated phase CML, 15% in myeloid blast phase CML,
and progresses towards the accelerated phase as in CHS, but differs from CHS in view of the absence of giant intracytoplasmic granules in the leukocytes observed either in the peripheral blood smear or by genetic analysis.
The accelerated phase is defined as the presence of 1% to 19% blasts in the blood or bone marrow, basophils> 20%, thrombocytosis or thrombocytopenia not related to therapy, and clonal evolution in cytogenetic evaluation.
24 different BCR-ABL mutations were noted in 42% of chronic phase and 54% of accelerated phase CML patients who were evaluated for mutations.
they were more frequent in patients with accelerated phase CML or blast crisis as compared to patients with chronic phase CML.
disease being treated and they were more frequent in patients with accelerated phase CML or blast crisis as compared to patients with.
The presence of BCR-ABL mutations increases the risk by 52% of chronic-phase CML patients evolving to the accelerated phase or blast crisis within nine months NNH: 2. These mutations, especially P-loop mutations, also reduce the time free of disease progression
Treatment with 400 mg of imatinib produced higher major and complete cytogenetic response rates compared to the interferon and cytarabine combination in initial chronic-phase CML patients 87.1% vs. 34.7% and higher survival free of progression to the accelerated phase and blast crisis 96.7% vs. 91.5%; p-value< 0.001 A.
Accelerated phase is defined by the presence of any of the following: blasts≥ 15% but<
Ph+ ALL, the median duration of treatment was 14 months for accelerated phase CML, 3 months for myeloid blast CML,
blast or accelerated phase disease, other Ph+ leukaemias
with new abnormalities in addition to the Philadelphia chromosome*Increasing splenomegaly or white blood cell count, unresponsive to therapyThe patient is considered to be in the accelerated phase if any of the above are present.
intolerant CML in chronic phase(n=321) and accelerated phase(n=137) treated at the recommended dose of 400 mg twice daily.
Due to the lower cost, resistance to imatinib, or advanced stages of the disease accelerated phase and blast crisis,
intolerant CML in chronic phase(n=321) and accelerated phase(n=137) treated at the recommended dose of 400 mg twice daily.
