Voorbeelden van het gebruik van Total clearance in het Engels en hun vertalingen in het Nederlands
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Renal elimination of parent drug accounts for about 60 to 70% of total clearance of systemically available glycopyrronium whereas non-renal clearance accounts for about 30 to 40.
In HIV-infected patients, total clearance of stavudine is 594±164 ml/min,
The total clearance of retigabine from plasma following intravenous dosing is typically 0.4 to 0.6 l/h/kg.
However, patients with positive neutralizing antibodies responses had decreased total clearance(CL) values
accounts for 50- 60% of total clearance, and is related to creatinine clearance. .
Total clearance for levodopa is in the range of 0.55-1.38 l/ kg/ h
In volunteers with normal kidney function, total clearance(Cltot) amounts to 170 ml/min/1.73 m2
Total clearance of ibandronic acid was reduced to 44 ml/min in the subjects with severe renal impairment compared with 129 mL/min in subjects with normal renal function.
In the presence of metabolic inhibitors, renal clearance may account for up to 70% of total clearance of maraviroc, hence renal impairment may result in increased maraviroc exposures in this case.
However, renal clearance contributes less than 25% of maraviroc total clearance in the absence of CYP3A4 inhibitors,
Total clearance of stavudine is 594±164 ml/ min, and renal clearance is 237±98 ml/ min,
Following daily administration of a 20 mg dose of tafamidis meglumine for 14 days in healthy subjects, mean steady-state half-life was 59 h and mean total clearance was 0.42 l/h.
The results of 3 phase III pivotal efficacy studies showed that treatment with imiquimod for sixteen weeks was significantly more effective than treatment with vehicle as measured by total clearance of treated warts.
its renal clearance is 0.62 l/ h about 30% of total clearance.
The main measure of effectiveness was the number of patients with total clearance of treated warts.
The total clearance of iloprost is about 20 ml/kg/min,
In those imiquimod patients who achieved total clearance of their warts, the median time to clearance was 8 weeks.
In healthy subjects, the total clearance is estimated as 22(± 3) L/hour; 50% is renally cleared 11 L/hour.
The main measure of effectiveness was the number of patients with total clearance of the tumours after 12 weeks.
No correlation between creatinine clearance and total clearance was observed in cancer patients,