At this time, sensitivity, specificity, and positive- or negative-predictive value of PET scanning and its enhancement of staging accuracy are uncertain.
Disease association, antibody prevalence and specificity Systemic lupus erythematosus(SLE), depending on method used and on the activity status of patients, antibody prevalence varies between less than 30% and more than 90.
A specificity decrease of 2.4% results in 5 times more biopsies of non-celiac children, most of which could be avoided by using the assay with the higher specificity.
Furthermore, a clinically useful test must have a high PPV(a parameter derived from sensitivity, specificity, and disease prevalence in the screened population).
However, the specificity and sensitivity of these markers have not been assessed in a screening setting in a general population, but several such studies are under way.
Sensitivity(the percentage of true-positive cases that are detected by the screening test) and specificity(the percentage of true-negative cases that are negative by the screening test) could be calculated.
Following, potential cut points for both diagnosis and prognosis were identified, and their sensitivity, specificity, as well as positive and negative predictive values(PPV, NPV) were estimated.
Sensitivity and specificity characteristics were evaluated, and the optimal cutoff score of 7 was identified, resulting in a sensitivity of 0.81 and a specificity of 0.85 for detecting depression.
The median sensitivity and specificity of 18F-FDG PET scanning in patients with normal-sized mediastinal lymph nodes were 82% for sensitivity and 93% for specificity.
In a study of patients who were on a waiting list for liver transplantation, ultrasonography was found to have a sensitivity of 58%, a specificity of 94%, a negative predictive value of 91%, and a PPV of 68.
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