Current research indicates that this test will detect 75 to 85 percent of neural tube defects(such as spina bifida and anencephaly) and 60 percent of Down syndrome in babies of women younger than 35, and 75 percent of neural tube defects and Down syndrome in babies of women 35 and older.
Although all women of childbearing age are at risk of having a pregnancy affected by neural tube defects and should take folic acid supplementation, some factors increase their risk, including a personal or family history(first- or second-degree relative) of neural tube defects.
Current research indicates that this test will detect 75 to 85 percent of neural tube defects(defects in the spine or head) and 60 percent of Down syndrome in babies of women younger than 35, and 75 percent of neural tube defects and Down syndrome in babies of women 35 and older.
Likewise in the U.S.: despite the effectiveness of vitamin B9(folic acid) supplementation in preventing neural tube defects, it appears that less than half of women in the U.S. who become pregnant follow the recommendation─ either out of ignorance or because of unplanned pregnancy(43).
Insufficient folate intake by pregnant women can cause birth defects such as spina bifida and neural tube defects, and the Food and Nutrition Board of the National Academies of Sciences, Engineering, and Medicine recommends that all women of childbearing age should get the RDA(400 micrograms) of folate, or 600 micrograms if they are pregnant.
The evidence became so overwhelming that the FDA finally had to reverse their previous position and acknowledge the association and allow folic acid supplements and high folic acid containing foods to claim that“daily consumption of folic acid by women of childbearing age may reduce the risk of neural tube defects.”.
神経管欠損症(NTD)。
Neural tube defects(NTD).
Spinabifidaおよび他の神経管欠損。
Spina bifida and other spinal defects.
おそらく、胎児における神経管欠損は、葉酸欠乏症と関連する最も一般的な問題である。
Perhaps neural tube defects in fetuses are the most common problem associated with folate deficiency.
神経管欠損は、米国では出産500〜1000人に1人の割合で発生しています。
In the United States, neural tube defects occur in 1 of 500 to 1,000 births.
There is also suggestive evidence that the promoter haplotype of the PDGFRA is associated with genetic susceptibility in human neural tube defects(NTDs).
Those planning on getting pregnant should begin taking folic acid 2-3 months prior to conception in order to prevent birth defects such as spina bifida or other neural tubedefects..
Since the discovery of the link between insufficient folic acid and neural tube defects(NTDs), governments and health organizations worldwide have made recommendations concerning folic acid supplementationfor women intending to become pregnant.
However, the prevention of neural tubedefects(NTD) was not considered when setting the RDA for pregnant women because the crucial events in the development of the neural tube occur before many women are aware that they are pregnant(10).
She reported 37 cases of serious deformities, many of them neural tube defects[birth defects of the brain and spinal column including spina bifida and anencephaly], with accompanying heart problems.
Most of these tests are offered primarily to couples with an increased risk of having a baby with a genetic abnormality(particularly neural tube defects) or a chromosomal abnormality(particularly when the woman is aged 35 or older).
葉酸は、赤ちゃんの神経管欠損の発生防止に役だちます。
Folic acid lessens or prevents the occurrence of neural tube defects in the baby.
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