In this process, platelets adhere to the damaged cell wall through binding of vWF(von Willerbrand factor) attached to collagen beneath vascular endothelial cells and GPIbα(glycoprotein Ibα) found on the platelet surface.
The thrombocytes are especially important for our blood clotting: If a vessel is injured, the platelets seal the injured site by the inside of the vessel wall and store each other.
Normally, the bone marrow produces: red blood cells(which carry oxygen in the blood) various types of white blood cell(which are part of the immune system) platelets which are involved in blood clotting.
TGF or transforming growth factor, beta-1 is another growth factor is that originates in bone, platelets, and in numerous other types of cells in the body.
For example, hematopoietic stem cells in the bone marrow are pluripotential and differentiate into various types of blood cells: red blood cells, white blood cells(neutrophiles, leukocytes and lymphocytes) and thrombocytes.
Cooperation Increase the likelihood of bleeding drugs, affecting blood coagulation(Heparin), platelet function(NSAIDs, dipiridamol), leading to the development of ulcerations and bleeding from the gastrointestinal tract.
PRP is produced using a centrifuge in a clean state, separating platelets from red blood cells and other components at high speed, and extracting them so as not to break or damage the platelets.
必要な場合-血液成分の輸血,血小板や白血球質量,広域抗生物質の任命。
if necessary- transfusion of blood components, platelet and leukocyte mass, the appointment of broad-spectrum antibiotics.
In order to prepare enriched plasma with cell growth factors, sonication is a very effective and efficient method to lyse the cell membranes and to release almost the complete cell growth factors from the platelets.
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