In conclusion, LFD resulted in reduced activation of microglia, which might be an underlying mechanism for the protective role of caloric restriction during aging-associated decline.
研究人员开始测试减少小胶质细胞数量或活动水平的影响。
The researchers started to test the effects of reducing the microglial or its level of activity.
如果只能恢复正常功能,那么小胶质细胞治疗只会对那些小胶质细胞存在缺陷的人有用。
If you can only restore normal function, then microglial treatments will be only useful for people who have microglial deficiency.
小胶质细胞是一种免疫细胞,它能对大脑中任何感染或损伤的迹象做出反应。
The microglia are the immune cells that respond to any signs of infection or damage in the brain.
To address the role of microglia in SLE, Diamond and colleagues analyzed mice that produce DNRAbs capable of penetrating the brain and inducing memory loss.
MCC950有效'冷却大脑',降低小胶质细胞炎症活动,让神经元正常运作。
MCC950 effectively'cooled the brains on fire', turning down microglial inflammatory activity, and allowing neurons to function normally.".
研究人员开始测试减少小胶质细胞数量或活动水平的影响。
The researchers began by testing the effects of reducing either the number of microglia or their level of activity.
XPro1595靶向神经炎症是导致小胶质细胞激活和神经细胞死亡的罪魁祸首。
XPro1595 targets neuroinflammation, which causes microglial activation and neuronal cell death.
Sisodia认为小胶质细胞在这种情况下可能会过度表现其免疫系统的作用。
Sisodia thinks the microglia could be overplaying their immune system role in this case.
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential link between Alzheimer's disease and systemic inflammation.
他认为这一关于小胶质细胞作用的发现开启了另一条了解阿尔茨海默病生物学的重要途径。
He feels that this discovery about the microglia's role opens another important avenue toward understanding the biology of Alzheimer's disease.
对阿尔茨海默氏症和帕金森病患者的大脑进行死后分析表明小胶质细胞激活在这些神经退行性疾病中很常见。
Postmortem analysis of brains from Alzheimer's and Parkinson's disease patients shows that microglial activation is common in these neurodegenerative diseases.
ABCA7在各种组织中表达,并显示在CNS神经元和小胶质细胞中富集(4)。
ABCA7 is expressed in a variety of tissue and exhibits neuronal and microglial enrichment in the CNS(4).
The researchers discovered that this could be explained by the fact that TREM2 induces microglia to produce a substance called ApoE, which enhances aggregate formation.
Dr. Kiavash Movahedi(VIB Center for Inflammation Research, VUB):"While microglia are fairly well studied, other brain macrophages have remained quite enigmatic.
This means that as we age and our chronic inflammation increases, more and more macrophages, including microglia, shift towards this M1 profile.
一种理论称,情绪创伤(以及身体创伤和环境毒素)可能刺激中枢神经系统中一种名为“小胶质细胞”的分子。
One theory is that emotional trauma(as well as physical injury or environmental toxins) may stimulate molecules in your central nervous system called microglia.
The researchers plan to investigate how consumption of high-fat foods leads to the activation of microglia, and whether there are ways to block these signals.
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