The new genomic analysis confirmed that T-ALL was driven by mutations in known signaling pathways, including JAK- STAT, Ras and PTEN- PI3K.
物体内在规定生长的同源异型框基因(Hox)家族中的突变就能够带来复杂的后果。
Mutations that arise in the homeobox( Hox) family of development-regulating genes in animals can also have complex effects.
这可能有帮助防止癌细胞形成可信来源因为DNA中的突变。
This may help in preventing cancer cells from forming because of mutations in the DNA.
研究人员还发现,先天性心脏病患儿携带大量在大脑发育过程中表现活跃的基因中的突变。
The scientists also found that children with congenital heart disease carry large numbers of mutations in genes that are active during brain development.
In addition, TNDM initiated by the genes, KCNJ11 or ABCC8 mutations are similar to mutations in chromosome 6q24-related to TNDM.
医学成像中使用的低剂量辐射会导致细胞培养中的突变.
Low doses of radiation used in medical imaging lead to mutations in cell cultures.
随后,苏海尔团队转向基因组数据,寻找现实世界人口中的突变分布情况。
Then the group of researchers turned to the genomic data, looking for the distribution of mutations in real-world populations.
这将涉及获取病史,进行医学检查和安排基因测试(特别是对于NIPBL基因中的突变)。
This will involve taking a medical history, carrying out a medical examination and arranging genetic testing(especially for mutations in the NIPBL gene).
This technology helps researchers connect mutations in the so-called genomic“dark matter” with the genes they affect, potentially revealing new therapeutic targets for genetic disorders.
This technology helps researchers connect mutations in the so-called genomic"dark matter" with the genes they affect, potentially showing new therapeutic targets for genetic disorders.
他们还发现,膜联蛋白A11中的致病突变阻止了搭便车,这反过来又阻止了RNA被传递到神经元的远端。
They also found that disease-causing mutations in annexin A11 prevented hitchhiking, which, in turn, prevented RNA from being delivered to the far reaches of neurons.
However, current genome-editing methods cannot efficiently correct these mutations in cells, and often cause random nucleotide insertions or deletions(indels) as a byproduct.
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