SMANJIVANJE DOZE in English translation

• dose reduction
• reducing the dose
• dose reductions
• tapering of the dose

Examples of using Smanjivanje doze in Croatian and their translations into English

za vrijeme 6 mjeseci u liječenju dermatitis herpetiformis može omogućiti smanjivanje doze približno 50%
during 6 months in the treatment of dermatitis herpetiformis may allow a reduction in dose of approximately 50%

Kod senzorne neuropatije 3. stupnja potrebno je obustaviti liječenje do oporavka na stupanj 1 ili 2, nakon čega slijedi smanjivanje doze za sve naredne cikluse liječenja.
For Grade 3 sensory neuropathy, withhold treatment until resolution to Grade 1 or 2, followed by a dose reduction for all subsequent courses.

Ispitivanje se sastojalo od dva dijela s dvije neovisne primarne mjere ishoda uspješno smanjivanje doze steroida i vrijeme do naglog pogoršanja bolesti.
The study consisted of two parts with two independent primary endpoints successful steroid taper and time to flare.

odgađanje doze, smanjivanje doze i prekid liječenja u usporedbi s bolesnicima ≤ 75 godina(n=105) kad su primali ONIVYDE+5-FU/LV u ispitivanju adenokarcinoma gušterače.
dose delay, dose reduction and discontinuation compared to patients≤ 75 years(n=105) when treated with ONIVYDE+5-FU/LV in the pancreatic adenocarcinoma study.

Smanjivanje doze lijeka PegIntron u djece
Dose reduction of PegIntron in children

jetrom valja razmotriti smanjivanje doze ketokonazola kada se daje istodobno s ritonavirom doziranim kao antiretrovirusnim lijekom ili kao farmakokinetičkim pojačivačem.
hepatic adverse reactions, a dose reduction of ketoconazole should be considered when co-administered with ritonavir dosed as an antiretroviral agent or as a pharmacokinetic enhancer.

U bolesnika s oslabljenom funkcijom bubrega valja razmotriti smanjivanje doze klaritormicina- bolesnicima s klirensom kreatinina od 30 do 60 ml/min dozu treba smanjiti za 50%,
For patients with renal impairment, a clarithromycin dose reduction should be considered: for patients with creatinine clearance of 30 to 60 ml/min the dose

fazi liječenja kolatnom kiselinom, ali to nije indikacija za smanjivanje doze ako razina GGT-a nije povišena
do not indicate the need for a dose reduction if Gamma GT is not elevated

Za ostale indikacije smanjivanje doze u starijih bolesnika nije potrebno,
For other indications, no dose reduction is necessary in the elderly patients,

Bolesnici s porastom transaminaza moraju biti zbrinuti privremenim prekidom liječenja bosutinibom(nužno je razmotriti smanjivanje doze nakon oporavka do 1. stupnja
Patients with transaminase elevations should be managed by withholding bosutinib temporarily(with consideration given to dose reduction after recovery to grade 1

Potreban je oprez kada se lapatinib primjenjuje istodobno s lijekovima uske terapijske širine koji su supstrati za Pgp, a smanjivanje doze Pgp supstrata potrebno je uzeti u obzir.
Caution should be exercised when dosing lapatinib concurrently with medicinal products with narrow therapeutic windows that are substrates of Pgp, and a reduction in the dose of the Pgp substrate should be considered.

što upućuje na činjenicu da smanjivanje doze hidroksikarbamida za 50% može biti prikladno za bolesnike kod kojih je CrCl< 60 ml/min.
approximately 51% higher than in patients with a CrCl≥60 ml/min, which suggests that a dose reduction of hydroxycarbamide by 50% may be appropriate in patients with a CrCl< 60 ml/min.

Tablica 3 Raspored smanjivanja doze kapecitabina ciklusi od 3 tjedna
Table 3 Capecitabine dose reduction schedule 3 weekly cycle

Tablica 4 Raspored smanjivanja doze kapecitabina ciklusi od 3 tjedna ili kontinuirano liječenje.
Table 4 Capecitabine dose reduction shedule3-weeklycycle or continuous treatment.

Ove nuspojave jenjavaju nakon smanjivanja doze i upućuju na predoziranje.
These reactions abated after dose reduction and are suggestive of overdose.

Pažljivo treba razmotriti potrebu smanjivanja doze ili prekida terapije.
A reduction of dosage or termination of therapy should be carefully considered.

Preporučuje se smanjivanje doza u bolesnika s umjerenim ili teškim oštećenjem funkcije
Dose reduction is recommended for patients with moderate

Preporučuje se smanjivanje doza kod teških ili upornih neutropenija
Dose reductions are recommended for severe

Nadalje, ti se događaji mogu također zbrinjavati privremenim prekidom liječenja bosutinibom, smanjivanjem doze i/ili trajnim prekidom liječenja bosutinibom vidjeti dijelove 4.2 i 4.8.
In addition, these events can also be managed by withholding bosutinib temporarily, dose reduction, and/or discontinuation of bosutinib see sections 4.2 and 4.8.

Mijelosupresija se mora/smije zbrinjavati privremenim prekidom bosutiniba, smanjivanjem doze i/ili trajnim prekidom liječenja bosutinibom vidjeti dijelove 4.2 i 4.8.
Myelosuppression should/can be managed by withholding bosutinib temporarily, dose reduction, and/or discontinuation of bosutinib see sections 4.2 and 4.8.