Examples of using Is a substrate in English and their translations into Croatian
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In vitro olaparib is a substrate for the efflux transporter P-gp
In vitro, apremilast is a substrate, and a weak inhibitor of P-glycoprotein(IC50>
Milbemycin oxime is a substrate for P-glycoprotein(P-gp) and therefore could interact with other P-gp substrates(for example, digoxin, doxorubicin)
In vitro studies showed that umeclidinium bromide is principally metabolised by cytochrome P450 2D6(CYP2D6) and is a substrate for the P-glycoprotein(P-gp) transporter.
In vitro studies showed that vilanterol is primarily metabolised by cytochrome P450 3A4(CYP3A4) and is a substrate for the P-gp transporter.
Based on in vitro studies, guanfacine is a substrate of OCT1 and OCT2,
Empagliflozin is a substrate of the human uptake transporters OAT3,
When efavirenz is co-administered with an anticonvulsant that is a substrate of CYP450 isoenzymes, periodic monitoring of anticonvulsant levels should be conducted.
Guanfacine is a substrate of CYP3A4 and CYP3A5,
The tape itself is a substrate of a dielectric material, not more than 0.25 mm thick,
In vitro: Cysteamine bitartrate is a substrate of P-gp and OCT2,
the active metabolite is a substrate for, or an inhibitor of, the major cytochrome P450 isoforms.
Maraviroc is a substrate of CYP3A and its plasma concentration increases when co-administered with potent CYP3A inhibitors.
Posaconazole is metabolised via UDP glucuronidation(phase 2 enzymes) and is a substrate for p- glycoprotein(P-gp) efflux in vitro.
Sofosbuvir is a substrate of drug transporter P-gp
Edoxaban is a substrate for the efflux transporter P-glycoprotein(P- gp),
osimertinib is a substrate of P-glycoprotein and breast cancer resistant protein(BCRP),
Cabozantinib is a substrate for CYP3A4 metabolism in vitro,
Cabozantinib is a substrate for CYP3A4 metabolism in vitro,
Preclinical studies indicate that aliskiren might be a substrate of organic anion transporting polypeptides.