REPEAT DOSE in Croatian translation

• ponovljenih doza
• ponovljene doze

Examples of using Repeat dose in English and their translations into Croatian

In a repeat dose toxicity study in juvenile rats,
U ispitivanju toksičnosti ponovljenih doza na juvenilnim štakorima,

No effects on electrocardiograms, including QT and QTc intervals, were seen in a repeat dose safety pharmacology study in monkeys at maximal plasma concentrations 8.9-fold greater than the concentrations obtained at therapeutic doses in humans with 300 mg intravenous infusion administration.
U farmakološkom ispitivanju sigurnosti ponovljenih doza u majmuna nisu uočeni učinci na elektrokardiograme, uključujući QT i QTc-intervale, pri maksimalnim koncentracijama u plazmi koje su bile 8, 9 puta veće od koncentracija koje se postižu terapijskim dozama u ljudi uz primjenu intravenske infuzije od 300 mg.

During repeat dose toxicology studies in dogs, an acute response characterised by hypotension,
Za vrijeme ispitivanja toksičnosti ponovljene doze u pasa, nakon primjene pegiliranih liposoma(placebo)

no notable effects in the male and female reproductive organs in repeat dose toxicity studies in mice(see section 5.3).
u ispitivanjima toksičnosti ponovljenih doza u miševa nije bilo zamjetnih učinaka na reproduktivne organe mužjaka i ženki(vidjeti dio 5.3).

several other less adverse effects were found in the repeat dose studies; in particular decreased body weight gain,
utvrđeno je nekoliko drugih manje štetnih učinaka u ispitivanjima ponovljene doze; posebice smanjeno povećanje tjelesne težine,

Taken together, the liver changes observed in experimental animals in repeat dose toxicity studies are regarded as adaptive changes due to enzyme induction
U cjelini, promjene na jetri primijećene u eksperimentalnim životinjama u ispitivanjima toksičnosti ponovljenih doza, smatraju se adaptivnim promjenama uslijed indukcije enzima, a zbog pomanjkanja kliničkih znakova nije vjerojatno

In repeat dose toxicology studies in rat
U ispitivanjima toksičnosti ponovljene doze u štakora i psa,

the total systemic exposure after repeat dose administration(AUClast) was equivalent for subcutaneous
ukupna sistemska izloženost nakon primjene ponovljenih doza(AUCtrajanja) bila je jednaka za supkutane

One out of two 26-week rat repeat dose studies, initiated in 4-5 weeks old rats, showed a dose related increase of the incidence of malignant hibernoma,
Jedno od dva ispitivanja ponovljene doze u trajanju od 26 tjedana u štakora započeto u 4-5 tjedana starih štakora pokazalo je povećanje incidencije malignog hibernoma,

No treatment- related effects have been identified in reproductive tissues of either sex during repeat dose intravenous toxicity studies of up to four weeks in the rat and two weeks in monkeys.
Učinci povezani s liječenjem nisu utvrđeni na reproduktivnom tkivu niti jednog spola tijekom intravenskih ispitivanja toksičnosti ponovljenih doza u trajanju do četiri tjedna u štakora i dva tjedna u majmuna.

A study in 40 healthy volunteers showed that the co-administration of single dose eltrombopag 100 mg with repeat dose LPV/RTV 400 /100 mg twice daily resulted in a reduction in eltrombopag plasma AUC(0-) by 17% 90% CI: 6.6%, 26.6.
Ispitivanje s 40 zdravih dobrovoljaca pokazalo je da istodobna primjena jedne doze eltrombopaga od 100 mg s ponovljenim dozama LPV/RTV od 400/100 mg dva puta dnevno rezultira smanjenjem plazmatskog AUC(0-) eltrombopaga za 17% 90% CI: 6,6%, 26, 6.

An open label, repeat dose study(3 cycles of 6 weeks of treatment,
Otvoreno ispitivanje s ponavljanim dozama(3 ciklusa po 6 tjedana liječenja, nakon kojih su

Cataracts and lens opacities were observed in the repeat dose rodent toxicology and carcinogenicity studies, but were not observed in dogs
Katarakta i opacifikacija leća primijećena je u studijama toksikologije i karcinogeničnosti s ponovljenim dozama u glodavaca, ali nisu primijećeni u pasa i majmuna

An adverse effect on female fertility can however be expected as repeat dose toxicity studies in animals have shown inhibition of the maturation of ovarian follicles
Može se, međutim, očekivati nepovoljan utjecaj na plodnost žena jer su ispitivanja toksičnosti ponovljenih doza na životinjama pokazala inhibiciju sazrijevanja folikula u jajnicima i smanjenje/odsutnost žutog tijela

The main findings observed in repeat dose toxicity studies in rats and dogs comprised atrophic,
Glavni nalazi opaženi u ispitivanjima toksičnosti ponovljenih doza u štakora i pasa sastojali su se od atrofičnih,

If you do not respond sufficiently to the repeat dose, a third dose of Ilaris at 300 mg
Ako ne odgovorite dostatno na ponovljenu dozu, može se razmotriti treća doza Ilarisa od 300 mg

In repeat dose studies in rodents,
U ispitivanjima s ponovljenim dozama na glodavcima čini se

hypospermia were present in rats after repeat doses.
hipospermija bile su prisutne u štakora nakon ponovljenih doza.

Repeated doses of 200 mg ketoconazole daily resulted in a 17-fold increase in dronedarone exposure.
Ponovljene doze od 200 mg ketokonazola dnevno uzrokovale su17- erostruko povećanje izloženosti dronedaronu.

The pharmacokinetics of safinamide are linear after single and repeated doses.
Farmakokinetika safinamida je linearna nakon jedne i ponovljenih doza.