Examples of using P-gp in English and their translations into Danish
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In experimental animals, it has been shown that P-gp is a major determinant of Tekturna bioavailability.
In experimental animals, it has been shown that P-gp is a major determinant of Rasilez bioavailability.
In experimental animals, it has been shown that P-gp is a major determinant of Riprazo bioavailability.
In experimental animals, it has been shown that P-gp is a major determinant of Sprimeo bioavailability.
In experimental animals, it has been shown that P-gp is a major determinant of Enviage bioavailability.
other moderate P-gp inhibitors itraconazol,
modify CYP3A4 and/ or P-gp activity(see"Other potential interactions") may modify the pharmacokinetics of saquinavir.
The inhibitory effect of ritonavir(with or without other protease inhibitors) on P-gp activity may decrease over time eg digoxin
These active substances are strong inhibitors of both CYP3A4 and P-gp and therefore may increase rivaroxaban plasma concentrations to a clinically relevant degree which may lead to an increased bleeding risk see section 4.5.
P-gp potent inhibitors A single dose drug interaction study in healthy subjects has shown that ciclosporin(200
Moderate P-gp inhibitors Co-administration of aliskiren 300 mg with ketoconazole 200 mg resulted in a 76% increase in aliskiren AUC but P-gp inhibitors such as ketoconazole are expected to increase tissue concentrations.
it is known that P-gp also controls tissue uptake of a variety of substrates and P-gp inhibitors can increase the tissue-to-plasma concentration ratios.
Moderate P-gp inhibitors Co-administration of aliskiren 300 mg with ketoconazole 200 mg resulted in a 76% increase in aliskiren AUC but P-gp inhibitors such as ketoconazole are expected to increase tissue concentrations more than plasma concentrations.
Laropiprant is not a substrate of human P-gp, and therefore other inhibitors of CYP3A4 and/ or P-gp are also not expected to have a clinically meaningful impact on the pharmacokinetics of laropiprant.
changing the zonisamide dose in patients who are also receiving drugs which are P-gp substrates e. g. digoxin, quinidine.
considered as strong CYP3A4 inhibitor and moderate P-gp inhibitor, led to a 1.5 fold increase in mean rivaroxaban AUC and a 1.4 fold increase in Cmax.
CYP3A4 and P-gp inhibitors Co-administration of rivaroxaban with ketoconazole(400 mg once a day[od])
inhibit the transport protein, P-glycoprotein(P-gp) in vitro.
Increased plasma concentrations of P-gp substrates such as digoxin cannot be excluded with concomitant treatment with sorafenib.