Examples of using Pgp in English and their translations into Romanian
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also an inhibitor of Pgp.
Co- administration of APTIVUS and medicinal products that inhibit Pgp may increase tipranavir plasma concentrations.
Furthermore, ambrisentan did not induce MRP2, Pgp or BSEP protein expression in rat hepatocytes.
due to lapatinib inhibition of CYP2C8 and/or Pgp.
It cannot be excluded that lapatinib will affect the pharmacokinetics of substrates of Pgp(e. g. digoxin),
Tipranavir is a Pgp substrate, a weak Pgp inhibitor
concomitant administration of ketoconazole, a Pgp inhibitor, has no effect on eribulin exposure(AUC and Cmax).
If patients require co-administration of a moderate CYP3A4 or PgP inhibitor, dose reduction to 5 mg daily or 2.5 mg daily may be considered.
In vitro data indicate that gefitinib is a substrate for the membrane transport protein Pgp.
Darunavir/ritonavir increases the plasma concentrations of clarithromycin as a result of CYP3A4 inhibition and possible Pgp inhibition.
Use caution when co-administration of moderate CYP3A4 inhibitors or PgP inhibitors cannot be avoided.
If patients require co-administration of a moderate CYP3A4 or PgP inhibitor, reduce the daily dose by approximately 50%.
Particular caution should be used when prescribing lopinavir/ritonavir in patients taking digoxin as the acute inhibitory effect of ritonavir on Pgp is expected to significantly increase digoxin levels.
CYP3A4, Pgp, and BCRP; therefore medicinal products that induce those enzymes may decrease dolutegravir plasma concentration
OATP1B3, Pgp and BCRP.
a substrate for Pgp(see section 5.2).
on CYP 3A and Pgp.
although ritonavir is a Pgp inhibitor, the net effect of APTIVUS, co-administered with low dose ritonavir, at the proposed dose regimen at steady-state, is Pgp induction.
Caution should be exercised when dosing lapatinib concurrently with medicinal products with narrow therapeutic windows that are substrates of Pgp, and a reduction in the dose of the Pgp substrate should be considered.
including the P-glycoprotein(Pgp), breast cancer resistance protein(BCRP), multi- drug resistance related protein 2(MRP2),