Examples of using A dose reduction in English and their translations into Swedish
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Medicine
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A dose reduction of approximately 50% is recommended for patients with hepatic impairment see section 4.2.
At retreatment a dose reduction may be considered according to the dose reduction schedule see Table 1.
If there is simultaneous use of lansoprazole, a dose reduction of phenytoin may be necessary.
5 x ULN were managed with a dose reduction or temporary suspension of lomitapide dosing, and all patients were
For other substrates of CYP3A4 a dose reduction or consideration of an alternative may be required Table 1.
cannot be managed with a dose reduction or supportive care.
Such effects should be discussed with the carer during treatment reviews and a dose reduction considered.
Patients with impaired liver function should be treated with extreme caution and a dose reduction should be considered see sections 4.3 and 4.4.
If the therapy over time is less tolerated at a given dose, symptomatic treatment and/or a dose reduction to the next lower dose should be considered.
followed by a dose reduction for all subsequent courses.
Elderly patients may require a dose reduction of pregabalin due to a decreased renal function see patients with renal impairment.
Although it is not a strong inhibitor of this enzyme, a dose reduction may be necessary for individually dose-titrated drugs that are metabolised by CYP2D6 See 4.5.
A dose reduction is recommended in patients with mildly
The need t o interrupt treatment after a dose reduction if serum creatinine rises:• Adults
who stopped vandetanib for an adverse event discontinued without a dose reduction.
Hepatic impairment Patients with hepatic impairment should be treated with extreme caution and a dose reduction should be considered see sections 4.2, 4.3 and 5.2.
therefore if signs or symptoms of tardive dyskinesia appear in a patient on olanzapine, a dose reduction or discontinuation should be considered.
A dose reduction of Ranexa may be needed in combination with:• Moderate CYP3A4 inhibitors(e. g. diltiazem,
If blood counts remain low, a dose reduction to 400 mg once daily may be required.
In patients who experienced severe haematological events, a dose reduction or treatment discontinuation is recommended see section 4.2.