Примери за използване на Therapeutic window на Английски и техните преводи на Български
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Coadministration of lapatinib with medicinal product with narrow therapeutic windows that are substrates of CYP3A4 or CYP2C8 should be
Indinavir with or without ritonavir should not be administered concurrently with medicinal products with narrow therapeutic windows and which are substrates of CYP3A4.
CYP3A4 with narrow therapeutic windows is not recommended.
Concomitant use of vemurafenib with agents metabolized by CYP3A4 with narrow therapeutic windows is not recommended.
Patients should be carefully monitored if co-treated with other medicinal products with especially emphasis to medicinal products with narrow therapeutic windows.
Caution should be exercised when dosing lapatinib concurrently with medicinal products with narrow therapeutic windows that are substrates of Pgp,
Coadministration of lapatinib with medicines with narrow therapeutic windows that are substrates of CYP3A4(e. g. cisapride,
Due to the large therapeutic window of clarithromycin no dose reduction should be necessary in patients with normal renal function.
Quinidine has a narrow therapeutic window and is contraindicated due to potential inhibition of CYP3A by atazanavir.
Esterified steroids are designed to extend the therapeutic window after administration, allowing less frequent injections than free(unesterified) steroids.
Pharmacokinetic/ pharmacodynamic relationships The literature on busulfan suggests a therapeutic window between 900 and 1500 µMol. minute for AUC.
Considering the narrow therapeutic window for ciclosporin, the CHMP requested the MAH to consider ciclosporin intake in order to reduce intra-individual variability.
A medicine with a narrow therapeutic window can easily cause side effects if given at a dose a little higher than the recommended dose.
Therefore, caution is recommended when administering Glivec with CYP3A4 substrates with a narrow therapeutic window(e. g. cyclosporin or pimozide).
narrow therapeutic window, diet and medication constraints, frequent laboratory observations
These recommendations should also be considered when rufinamide is used concomitantly with drugs with a narrow therapeutic window such as warfarin and digoxin.
Nitisinone treated patients who are concomitantly treated with medicinal products with a narrow therapeutic window metabolized through CYP2C9,
Therefore, caution is recommended when administering imatinib with CYP3A4 substrates with a narrow therapeutic window e.g. cyclosporin,
Other medicinal products with a narrow therapeutic window: some substances(e. g. lidocaine(by systemic route)
Diflucan treated patients who are concomitantly treated with medicinal products with a narrow therapeutic window metabolised through CYP2C9,